Czech: Šafařík or Slovak: Šafárik is a Slavic surname. Female version is Czech: Šafaříková or Slovak: Šafáriková. Notable people with the surname include:
- Pavel Jozef Šafárik (1795–1861), Slovak philologist, poet, Slavist, literary historian, historian and ethnographer
- Vojtěch Šafařík (1829–1902), Czech chemist, son of Pavel Jozef
- 8336 Šafařík, a main belt asteroid
- Šafařík (crater), a small lunar impact crater on the far side of the Moon