1-Boc-4-AP (tert-butyl 4-(phenylamino)piperidine-1-carboxylate) is a compound used as an intermediate in the manufacture of fentanyl, as well as various related derivatives such as butyrylfentanyl, furanylfentanyl, benzylfentanyl and homofentanyl, among others. It is an N-protected derivative of 4-anilinopiperidine which can be readily converted to fentanyl or related analogues in several straightforward synthetic steps. It was classified as a DEA List 1 Chemical in 2022, and is also controlled in various other jurisdictions. Its possession, sale and importation are consequently heavily regulated throughout much of the world.[1] 1-Boc-4-AP has also been identified as an impurity in other designer drug products, though it is unclear if it has any pharmacological activity in its own right.[2]
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| Formula | C16H24N2O2 |
| Molar mass | 276.380 g·mol−1 |
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See also
editReferences
edit- ^ "Specific Listing for 1-boc-4-AP, a Currently Controlled List I Chemical". Federal Register, 87 FR 67550-67553. 9 November 2022.
- ^ May C, Downey C, Power JD, Kavanagh PV (September 2020). "An unusual detection of tert-butyl-4-anilinopiperidine-1-carboxylate in seizures of falsified 'Xanax' tablets and in items in a suspected heroin seizure submitted by Irish law enforcement". Drug Testing and Analysis. 12 (9): 1387–1392. doi:10.1002/dta.2884. PMID 32567251. S2CID 219974817.