1E or 1-E may refer to:
- 1st meridian east, a longitude coordinate
- ISS 1E
- Astra 1E, a communications satellite owned and operated by SES, and launched in 1995
- California Proposition 1E (2009), a defeated California ballot proposition
- 1E, UIC classification of the 2-10-0 train arrangement
- 1E, a designator of celestial objects discovered via Einstein Observatory
- 1E, inc - Software Company specializing in Digital Employee Experience (DEX) Gartner