2'''-acetyl-6'''-hydroxyneomycin C deacetylase

2'''-acetyl-6'''-hydroxyneomycin C deacetylase (EC 3.5.1.113, neoL (gene)) is an enzyme with systematic name 2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming).[1] This enzyme catalyses the following chemical reaction

2'''-acetyl-6'''-hydroxyneomycin C deacetylase
Identifiers
EC no.3.5.1.113
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H2O 6'''-deamino-6'''-hydroxyneomycin C + acetate

This enzyme is involved in biosynthesis of aminoglycoside antibiotics of the [neomycin] family.

References

edit
  1. ^ Yokoyama K, Yamamoto Y, Kudo F, Eguchi T (April 2008). "Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis". ChemBioChem. 9 (6): 865–9. doi:10.1002/cbic.200700717. PMID 18311744.
edit