2-Deoxystreptamine N-acetyl-D-glucosaminyltransferase

2-deoxystreptamine N-acetyl-D-glucosaminyltransferase (EC 2.4.1.283, btrM (gene), neoD (gene), kanF (gene)) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:2-deoxystreptamine N-acetyl-D-glucosaminyltransferase.[1][2] This enzyme catalyses the following chemical reaction

2-deoxystreptamine N-acetyl-D-glucosaminyltransferase
Identifiers
EC no.2.4.1.283
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
UDP-N-acetyl-alpha-D-glucosamine + 2-deoxystreptamine UDP + 2'-N-acetylparomamine

Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics.

References

edit
  1. ^ Yokoyama K, Yamamoto Y, Kudo F, Eguchi T (April 2008). "Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis". ChemBioChem. 9 (6): 865–9. doi:10.1002/cbic.200700717. PMID 18311744.
  2. ^ Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ (October 2011). "Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation". Nature Chemical Biology. 7 (11): 843–52. doi:10.1038/nchembio.671. PMID 21983602.
edit