The First Stage of the 2010 Copa Santander Libertadores de América was run from January 26 to February 10.
Matches
edit| Teams | Scores | Tie-breakers | |||||
|---|---|---|---|---|---|---|---|
| 2nd leg home team | Points | 1st leg home team | 1st leg | 2nd leg | GD | AG | Pen. |
Libertad 
|
3:3 |  Deportivo Táchira
|
0–1 | 3–1 | +1:−1 | — | — |
Estudiantes Tecos 
|
0:6 |  Juan Aurich
|
0–2 | 1–2 | — | — | — |
Universidad Católica 
|
3:3 |  Colón
|
2–3 | 3–2 | 0:0 | 2:2 | 5–3 |
Cruzeiro 
|
4:1 |  Real Potosí
|
1–1 | 7–0 | — | — | — |
Emelec 
|
4:1 | Newell's Old Boys
|
0–0 | 2–1 | — | — | — |
Racing 
|
4:1 |  Junior
|
2–2 | 2–0 | — | — | — |
Match G1
edit| Deportivo Táchira | 1–0 | Libertad |
|---|---|---|
Maita  27' |
Report |
| Libertad | 3–1 | Deportivo Táchira |
|---|---|---|
| Rodolfo Gamarra 40' Velázquez 67', 81' |
Report | Boada 29' |
Deportivo Táchira and Libertad tied 3–3 on points. Libertad advanced on goal difference.
Match G2
edit| Juan Aurich | 2–0 | Estudiantes Tecos |
|---|---|---|
| Tejada 11', 60' |
Report |
| Estudiantes Tecos | 1–2 | Juan Aurich |
|---|---|---|
| Bareiro 77' |
Report | Tejada 41' Ciciliano 75' |
Juan Aurich advanced on points 6–0.
Match G3
edit| Universidad Católica | 3–2 | Colón |
|---|---|---|
| Henríquez 40' Toloza 74'Morales 83' |
Report | Moreno y Fabianesi 53' Fuertes 55' (pen.) |
| Penalties | ||
Toloza  Mirosevic Vranjicán Díaz Mannara |
5–3 | Coudet Moreno y Fabianesi Pellerano Rivarola |
Colón and Universidad Católica tied 3–3 on points, 0–0 on goal difference, and 2–2 on away goals. Universidad Católica advanced on penalties 5–3.
Match G4
edit| Real Potosí | 1–1 | Cruzeiro |
|---|---|---|
| Correa 88' |
Report | Wellington Paulista 7' |
| Cruzeiro | 7–0 | Real Potosí |
|---|---|---|
| Wellington Paulista 29' Thiago Ribeiro 30'Kléber 39'Jonathan 45'Eliandro 87'Bernardo 88'Guerrón 90+1' |
Report |
Cruzeiro advanced on points 4–1.
Match G5
edit| Emelec | 2–1 | Newell's Old Boys |
|---|---|---|
| Rojas 46' Quiñónez 65' |
Report | Barrientos 52' |
Emelec advanced 4–1 on points.
Match G6
edit| Junior | 2–2 | Racing |
|---|---|---|
| Acuña 12' Arzuaga 90+1' |
Report | Mirabajes 28' Pallas 67' |
Attendance: 18,026
Referee: Carlos Vera (Ecuador)
Racing advanced on points 4−1.