3,5,7-Trioxododecanoyl-CoA synthase

3,5,7-Trioxododecanoyl-CoA synthase (EC 2.3.1.206, TKS) is an enzyme with systematic name malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming).[1][2] This enzyme catalyses the following chemical reaction

3,5,7-Trioxododecanoyl-CoA synthase
Identifiers
EC no.2.3.1.206
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
3 malonyl-CoA + hexanoyl-CoA 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2

This polyketide synthase catalyse the first step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa.

References

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  1. ^ Taura F, Tanaka S, Taguchi C, Fukamizu T, Tanaka H, Shoyama Y, Morimoto S (June 2009). "Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway". FEBS Letters. 583 (12): 2061–6. doi:10.1016/j.febslet.2009.05.024. PMID 19454282. S2CID 13746503.
  2. ^ Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE (July 2012). "Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides". Proceedings of the National Academy of Sciences of the United States of America. 109 (31): 12811–6. Bibcode:2012PNAS..10912811G. doi:10.1073/pnas.1200330109. PMC 3411943. PMID 22802619.
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