DMPX

DMPX
Clinical data
ATC code	None;
Identifiers
	IUPAC name 3,7-Dimethyl-1-(2-propyn-1-yl)-3,7-dihydro-1H-purine-2,6-dione;
CAS Number	14114-46-6 ;
PubChem CID	99562;
ChemSpider	89948;
UNII	5YFR5SPS6T;
CompTox Dashboard (EPA)	DTXSID30161577 ;
ECHA InfoCard	100.162.258
Chemical and physical data
Formula	C10H10N4O2
Molar mass	218.216 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cn2cnc(c2c1=O)n(C)c(=O)n1CC#C;
	InChI InChI=1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3; Key:IORPOFJLSIHJOG-UHFFFAOYSA-N;

DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity to A₂ adenosine receptors, in contrast to the A₁ subtype receptors.^[1] DMPX had 28× and 15× higher potency than caffeine in blocking peripheral and central NECA-responses. The locomotor stimulation caused by DMPX (ED₅₀ 10 μmol/kg) was similarly higher than caffeine.^[1]

References

^ ^a ^b Seale TW, Abla KA, Shamim MT, Carney JM, Daly JW (1988). "3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs". Life Sciences. 43 (21): 1671–84. doi:10.1016/0024-3205(88)90478-x. PMID 3193854.

[DMPX-1] Seale TW, Abla KA, Shamim MT, Carney JM, Daly JW (1988). "3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs". Life Sciences. 43 (21): 1671–84. doi:10.1016/0024-3205(88)90478-x. PMID 3193854.

[1]

Clinical data

ATC code	None
Identifiers
IUPAC name 3,7-Dimethyl-1-(2-propyn-1-yl)-3,7-dihydro-1H-purine-2,6-dione
CAS Number	14114-46-6^Y
PubChem CID	99562
ChemSpider	89948
UNII	5YFR5SPS6T
CompTox Dashboard (EPA)	DTXSID30161577
ECHA InfoCard	100.162.258
Chemical and physical data
Formula	C₁₀H₁₀N₄O₂
Molar mass	218.216 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Cn2cnc(c2c1=O)n(C)c(=O)n1CC#C
InChI InChI=1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3 Key:IORPOFJLSIHJOG-UHFFFAOYSA-N

DMPX

See also

References