2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase (EC 1.1.1.312, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, LigC, ProD) is an enzyme with systematic name 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
Identifiers
EC no.1.1.1.312
Databases
IntEnzIntEnz view
BRENDABRENDA entry
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MetaCycmetabolic pathway
PRIAMprofile
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NCBIproteins
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+

Unsubstituted aliphatic or aromatic aldehydes or glucose cannot serve as substrate of this enzyme.

References

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  1. ^ Maruyama K, Ariga N, Tsuda M, Deguchi K (April 1978). "Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase". Journal of Biochemistry. 83 (4): 1125–34. PMID 26671.
  2. ^ Maruyama K (December 1979). "Isolation and identification of the reaction product of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase". Journal of Biochemistry. 86 (6): 1671–7. PMID 528534.
  3. ^ Maruyama K (February 1983). "Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase". Journal of Biochemistry. 93 (2): 557–65. PMID 6841353.
  4. ^ Masai E, Momose K, Hara H, Nishikawa S, Katayama Y, Fukuda M (December 2000). "Genetic and biochemical characterization of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase and its role in the protocatechuate 4,5-cleavage pathway in Sphingomonas paucimobilis SYK-6". Journal of Bacteriology. 182 (23): 6651–8. doi:10.1128/jb.182.23.6651-6658.2000. PMC 111406. PMID 11073908.
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