4-Hydroxycoumarin synthase

(Redirected from 4-hydroxycoumarin synthase)

4-hydroxycoumarin synthase (EC 2.3.1.208, BIS2, BIS3) is an enzyme with systematic name malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase.[1] This enzyme catalyses the following chemical reaction

4-hydroxycoumarin synthase
Identifiers
EC no.2.3.1.208
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins
malonyl-CoA + 2-hydroxybenzoyl-CoA 2 CoA + 4-hydroxycoumarin + CO2

This polyketide synthase can also accept benzoyl-CoA as substrate.

References

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  1. ^ Liu B, Raeth T, Beuerle T, Beerhues L (January 2010). "A novel 4-hydroxycoumarin biosynthetic pathway". Plant Molecular Biology. 72 (1–2): 17–25. doi:10.1007/s11103-009-9548-0. PMID 19757094.
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