51 may refer to:
- 51 (number)
- The year
- 51 (film), a 2011 American horror film directed by Jason Connery
- "Fifty-One", an episode of the American television drama series Breaking Bad
- 51 (album), a 2012 mixtape by rapper Kool A.D.
- "Fifty One", a song by Karma to Burn from the album V, 2011
- 51 Nemausa, a main-belt asteroid