5-Fluoro-EPT

5-Fluoro-EPT
Identifiers
	IUPAC name N-ethyl-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]propan-1-amine;
PubChem CID	156836218;
ChemSpider	129221323;
ChEMBL	ChEMBL5028990;
Chemical and physical data
Formula	C15H21FN2
Molar mass	248.345 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCN(CC)CCC1=CNC2=C1C=C(C=C2)F;
	InChI InChI=1S/C15H21FN2/c1-3-8-18(4-2)9-7-12-11-17-15-6-5-13(16)10-14(12)15/h5-6,10-11,17H,3-4,7-9H2,1-2H3; Key:QONMHCQBCANXJS-UHFFFAOYSA-N;

5-Fluoro-EPT (5F-EPT, 5-fluoro-N-ethyl-N-propyltryptamine) is a psychedelic tryptamine derivative related to drugs such as EPT and 5-MeO-EPT. It acts as a potent full agonist at the 5-HT_2A receptor with an EC₅₀ of 5.54 nM and an efficacy of 104% (compared to serotonin). It produces a head-twitch response in animal studies, and is claimed to have antidepressant activity.^[1]

References

^ WO 2021/168082, Kruegel AC, Sporn J, "Specific Tryptamines for use in the Treatment of Mood Disorders.", published 26 August 2021, assigned to Gilgamesh Pharmaceuticals, Inc..

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Identifiers

IUPAC name N-ethyl-N-[2-(5-fluoro-1H-indol-3-yl)ethyl]propan-1-amine
PubChem CID	156836218
ChemSpider	129221323
ChEMBL	ChEMBL5028990
Chemical and physical data
Formula	C₁₅H₂₁FN₂
Molar mass	248.345 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCN(CC)CCC1=CNC2=C1C=C(C=C2)F
InChI InChI=1S/C15H21FN2/c1-3-8-18(4-2)9-7-12-11-17-15-6-5-13(16)10-14(12)15/h5-6,10-11,17H,3-4,7-9H2,1-2H3 Key:QONMHCQBCANXJS-UHFFFAOYSA-N