5P or 5-P may refer to:
- 5p, an arm of Chromosome 5 (human)
- 5p- (or chromosome 5p deletion syndrome); see Cri du chat
- 5p, abbreviation for Five pence:
- GSAT-5P, an Indian communications satellite
- Team 5P, an animation production team
- Lim-5P, a model of PZL-Mielec Lim-6
- F9F-5P, a model of Grumman F9F Panther
- F6F-5P, a model of Grumman F6F Hellcat
- F4U-5P, a model of Vought F4U Corsair
- SV-5P, a model of Martin Marietta X-24A
- 5P Mara, a model of Dassault Mirage 5
- Typ 5P, a model of SEAT Toledo
- PI5P, abbreviation for Phosphatidylinositol 5-phosphate
- 5P, NASA ID for the Progress M-45 spacecraft
- 5P, a model of HP LaserJet 5
- 5 pillars in several contexts
- 5P, the production code for the 1980 Doctor Who serial State of Decay
- Five P's, the signs and symptoms of acute compartment syndrome