6-Hydroxy-3-succinoylpyridine 3-monooxygenase
(Redirected from 6-hydroxy-3-succinoylpyridine 3-monooxygenase)
6-hydroxy-3-succinoylpyridine 3-monooxygenase (EC 1.14.13.163, 6-hydroxy-3-succinoylpyridine hydroxylase, hspA (gene), hspB (gene)) is an enzyme with systematic name 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing).[1][2] This enzyme catalyses the following chemical reaction
| 6-hydroxy-3-succinoylpyridine 3-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.163 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
6-hydroxy-3-succinoylpyridine 3-monooxygenase catalyses a reaction in the nicotine degradation pathway of Pseudomonas species.
References
edit- ^ Tang H, Wang S, Ma L, Meng X, Deng Z, Zhang D, Ma C, Xu P (March 2008). "A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16". Applied and Environmental Microbiology. 74 (5): 1567–74. Bibcode:2008ApEnM..74.1567T. doi:10.1128/AEM.02529-07. PMC 2258644. PMID 18203859.
- ^ Tang H, Yao Y, Zhang D, Meng X, Wang L, Yu H, Ma L, Xu P (November 2011). "A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida". The Journal of Biological Chemistry. 286 (45): 39179–87. doi:10.1074/jbc.M111.283929. PMC 3234743. PMID 21949128.
External links
edit- 6-hydroxy-3-succinoylpyridine+3-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
