ABLIM1

Actin binding LIM protein 1, also known as ABLIM1, is a protein which in humans is encoded by the ABLIM1 gene.

ABLIM1
Identifiers
Aliases	ABLIM1, ABLIM, LIMAB1, LIMATIN, abLIM-1, actin binding LIM protein 1
External IDs	OMIM: 602330; MGI: 1194500; HomoloGene: 40994; GeneCards: ABLIM1; OMA:ABLIM1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q25.3 Start 114,431,112 bp End 114,768,061 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 D2|19 52.09 cM Start 57,021,165 bp End 57,303,351 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle cerebellar vermis cardiac muscle tissue of right atrium right ventricle mucosa of pharynx cerebellar hemisphere parotid gland gums gingival epithelium oral cavity Top expressed in cardiac muscle tissue of left ventricle conjunctival fornix right ventricle thymus lobe of cerebellum cerebellar vermis esophagus epithelium of stomach mesenteric lymph nodes subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding metal ion binding actin filament binding Cellular component cytoplasm lamellipodium cytoskeleton stress fiber actin cytoskeleton Biological process animal organ morphogenesis cytoskeleton organization lamellipodium assembly visual perception cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3983 226251 Ensembl ENSG00000099204 ENSMUSG00000025085 UniProt O14639 Q8K4G5 RefSeq (mRNA) NM_001003407 NM_001003408 NM_002313 NM_006720 NM_001322882 NM_001322883 NM_001322884 NM_001322885 NM_001322886 NM_001322887 NM_001322888 NM_001322889 NM_001322890 NM_001322891 NM_001322892 NM_001322893 NM_001322894 NM_001322895 NM_001322896 NM_001322897 NM_001322898 NM_001322899 NM_001322900 NM_001352440 NM_001352441 NM_001352442 NM_001352443 NM_001103177 NM_001103178 NM_001290813 NM_001290815 NM_001290816 NM_178688 NM_001347459 NM_001362445 NM_001362446 RefSeq (protein) NP_001003407 NP_001309811 NP_001309812 NP_001309813 NP_001309814 NP_001309815 NP_001309816 NP_001309817 NP_001309818 NP_001309819 NP_001309820 NP_001309821 NP_001309822 NP_001309823 NP_001309824 NP_001309825 NP_001309826 NP_001309827 NP_001309828 NP_001309829 NP_002304 NP_006711 NP_001339369 NP_001339370 NP_001339371 NP_001339372 NP_001096647 NP_001096648 NP_001277742 NP_001277744 NP_001277745 NP_001334388 NP_848803 NP_001349374 NP_001349375 Location (UCSC) Chr 10: 114.43 – 114.77 Mb Chr 19: 57.02 – 57.3 Mb PubMed search
Wikidata
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Function

This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified.

Interactions

ABLIM1 has been shown to interact with LDOC1.

External links

• Human ABLIM1 genome location and ABLIM1 gene details page in the UCSC Genome Browser.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Roof DJ, Hayes A, Adamian M, Chishti AH, Li T (August 1997). "Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein". The Journal of Cell Biology. 138 (3): 575–88. doi:10.1083/jcb.138.3.575. PMC 2141644. PMID 9245787.
• Kim AC, Peters LL, Knoll JH, Van Huffel C, Ciciotte SL, Kleyn PW, Chishti AH (December 1997). "Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers". Genomics. 46 (2): 291–3. doi:10.1006/geno.1997.5029. PMID 9417918.
• Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". The Journal of Biological Chemistry. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Ficarro SB, Salomon AR, Brill LM, Mason DE, Stettler-Gill M, Brock A, Peters EC (2005). "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites". Rapid Communications in Mass Spectrometry. 19 (1): 57–71. Bibcode:2005RCMS...19...57F. doi:10.1002/rcm.1746. PMID 15570572.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R (August 2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nature Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.