Disintegrin and metalloproteinase domain-containing protein 23 is a non-catalytic protein that in humans is encoded by the ADAM23 gene.[5][6] It is a member of the ADAM family of extracellular matrix metalloproteinases.

ADAM23
Identifiers
AliasesADAM23, MDC-3, MDC3, ADAM metallopeptidase domain 23
External IDsOMIM: 603710; MGI: 1345162; HomoloGene: 2826; GeneCards: ADAM23; OMA:ADAM23 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003812

NM_001177600
NM_011780

RefSeq (protein)

NP_003803

NP_035910

Location (UCSC)Chr 2: 206.44 – 206.62 MbChr 1: 63.49 – 63.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114948Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025964Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sagane K, Ohya Y, Hasegawa Y, Tanaka I (Aug 1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC 1219666. PMID 9693107.
  6. ^ a b "Entrez Gene: ADAM23 ADAM metallopeptidase domain 23".

Further reading

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