Centaurin, alpha 1

Arf-GAP with dual PH domain-containing protein 1 is a protein that in humans is encoded by the ADAP1 gene.

ADAP1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3FEH, 3FM8, 3LJU, 3MDB
Identifiers
Aliases	ADAP1, CENTA1, GCS1L, p42IP4, Centaurin, alpha 1, ArfGAP with dual PH domains 1
External IDs	OMIM: 608114; MGI: 2442201; HomoloGene: 55997; GeneCards: ADAP1; OMA:ADAP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p22.3 Start 897,900 bp End 955,407 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 139,257,631 bp End 139,311,377 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment hippocampus proper mucosa of transverse colon anterior cingulate cortex prefrontal cortex right frontal lobe primary visual cortex dorsolateral prefrontal cortex Brodmann area 9 temporal lobe Top expressed in primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell granulocyte jejunum cerebellar cortex piriform cortex pontine nuclei prefrontal cortex primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding GTPase activator activity inositol 1,3,4,5 tetrakisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol bisphosphate binding Cellular component cytoplasm plasma membrane nucleus cytosol Biological process regulation of GTPase activity cell surface receptor signaling pathway positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11033 231821 Ensembl ENSG00000105963 ENSMUSG00000056413 UniProt O75689 n/a RefSeq (mRNA) NM_006869 NM_001284308 NM_001284309 NM_001284310 NM_001284311 NM_172723 RefSeq (protein) NP_001271237 NP_001271238 NP_001271239 NP_001271240 NP_006860 n/a Location (UCSC) Chr 7: 0.9 – 0.96 Mb Chr 5: 139.26 – 139.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Centaurin, alpha 1 has been shown to interact with:

• Casein kinase 1, alpha 1
• Nucleolin,
• P110α,
• PRKCI,
• Protein kinase D1, and
• Protein kinase Mζ.

Further reading

• Venkateswarlu K, Cullen PJ (Aug 1999). "Molecular cloning and functional characterization of a human homologue of centaurin-alpha". Biochemical and Biophysical Research Communications. 262 (1): 237–44. doi:10.1006/bbrc.1999.1065. PMID 10448098.
• Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A (Jun 2001). "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". The Journal of Biological Chemistry. 276 (22): 18757–64. doi:10.1074/jbc.M010005200. PMID 11278595.
• Sedehizade F, Hanck T, Stricker R, Horstmayer A, Bernstein HG, Reiser G (Feb 2002). "Cellular expression and subcellular localization of the human Ins(1,3,4,5)P(4)-binding protein, p42(IP4), in human brain and in neuronal cells". Brain Research. Molecular Brain Research. 99 (1): 1–11. doi:10.1016/S0169-328X(01)00335-7. PMID 11869802.
• Whitley P, Gibbard AM, Koumanov F, Oldfield S, Kilgour EE, Prestwich GD, Holman GD (Apr 2002). "Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle". European Journal of Cell Biology. 81 (4): 222–30. doi:10.1078/0171-9335-00242. PMID 12018390.
• Reiser G, Bernstein HG (Dec 2002). "Neurons and plaques of Alzheimer's disease patients highly express the neuronal membrane docking protein p42IP4/centaurin alpha". NeuroReport. 13 (18): 2417–9. doi:10.1097/00001756-200212200-00008. PMID 12499840. S2CID 24499944.
• Dubois T, Zemlickova E, Howell S, Aitken A (Feb 2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochemical and Biophysical Research Communications. 301 (2): 502–8. doi:10.1016/S0006-291X(02)03010-3. PMID 12565890.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
• Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A (Aug 2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications. 307 (3): 459–65. doi:10.1016/S0006-291X(03)01187-2. PMID 12893243.
• Venkateswarlu K, Brandom KG, Lawrence JL (Feb 2004). "Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization" (PDF). The Journal of Biological Chemistry. 279 (8): 6205–8. doi:10.1074/jbc.C300482200. PMID 14625293. S2CID 34971745.
• Hanck T, Stricker R, Sedehizade F, Reiser G (Jan 2004). "Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins". Journal of Neurochemistry. 88 (2): 326–36. doi:10.1046/j.1471-4159.2003.02143.x. PMID 14690521. S2CID 19363530.
• Reiser G, Bernstein HG (Jan 2004). "Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin". NeuroReport. 15 (1): 147–8. doi:10.1097/00001756-200401190-00028. PMID 15106847. S2CID 23980496.
• Thacker E, Kearns B, Chapman C, Hammond J, Howell A, Theibert A (Oct 2004). "The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton". European Journal of Cell Biology. 83 (10): 541–54. doi:10.1078/0171-9335-00416. PMID 15679100.
• Lawrence J, Mundell SJ, Yun H, Kelly E, Venkateswarlu K (Jun 2005). "Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization". Molecular Pharmacology. 67 (6): 1822–8. doi:10.1124/mol.105.011338. PMID 15778454. S2CID 85844075.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Hayashi H, Matsuzaki O, Muramatsu S, Tsuchiya Y, Harada T, Suzuki Y, Sugano S, Matsuda A, Nishida E (Jan 2006). "Centaurin-alpha1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases". The Journal of Biological Chemistry. 281 (3): 1332–7. doi:10.1074/jbc.M505905200. PMID 16287813.
• Sedehizade F, von Klot C, Hanck T, Reiser G (Oct 2005). "p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor". Neurochemical Research. 30 (10): 1319–30. doi:10.1007/s11064-005-8804-1. PMID 16341594. S2CID 12972048.