ADP-specific glucokinase

(Redirected from ADP-dependent glucokinase)

In enzymology, an ADP-specific glucokinase (EC 2.7.1.147) also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reaction

ADP-specific glucokinase
Identifiers
EC no.2.7.1.147
CAS no.173585-07-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
ADPGK
Identifiers
AliasesADPGK, 2610017G09Rik, ADP-GK, ADP-specific glucokinase, ADP-dependent glucokinase, ADP dependent glucokinase
External IDsOMIM: 611861; MGI: 1919391; HomoloGene: 41739; GeneCards: ADPGK; OMA:ADPGK - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_028121
NM_001359282

RefSeq (protein)

NP_082397
NP_001346211

Location (UCSC)Chr 15: 72.75 – 72.79 MbChr 9: 59.2 – 59.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
ADP + D-glucose AMP + D-glucose 6-phosphate

Thus, the two substrates of this enzyme are ADP and D-glucose, whereas its two products are AMP and D-glucose 6-phosphate.

This enzyme belongs to the family of transferases, to be specific those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor.

In humans, the ADP-dependent glucokinase is encoded by the ADPGK gene.[5]

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GC5.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159322Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025236Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ronimus RS, Morgan HW (Mar 2004). "Cloning and biochemical characterization of a novel mouse ADP-dependent glucokinase". Biochemical and Biophysical Research Communications. 315 (3): 652–8. doi:10.1016/j.bbrc.2004.01.103. PMID 14975750.
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Further reading

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