ADP-specific phosphofructokinase

In enzymology, an ADP-specific phosphofructokinase (EC 2.7.1.146) is an enzyme that catalyzes the chemical reaction

ADP-specific phosphofructokinase
Identifiers
EC no.2.7.1.146
CAS no.237739-62-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
ADP + D-fructose 6-phosphate AMP + D-fructose 1,6-bisphosphate

Thus, the two substrates of this enzyme are ADP and D-fructose 6-phosphate, whereas its two products are AMP and D-fructose 1,6-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ADP:D-fructose-6-phosphate 1-phosphotransferase. This enzyme is also called ADP-6-phosphofructokinase, ADP-dependent phosphofructokinase.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U2X.

References

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  • Tuininga JE, Verhees CH, van der Oost J, Kengen SW, Stams AJ, de Vos WM (July 1999). "Molecular and biochemical characterization of the ADP-dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus". The Journal of Biological Chemistry. 274 (30): 21023–8. doi:10.1074/jbc.274.30.21023. PMID 10409652.