MCEF or Major Cdk9-interacting elongation factor is a transcription factor related to Af4. It is the fourth member of the Af4 family (AFF) of transcription factors, involved in numerous pathologies, including Acute Lymphoblastic Leukemia (ALL), abnormal CNS development, breast cancer and azoospermia.
| AF4/FMR2 family, member 4 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | AFF4 | ||||||
| NCBI gene | 27125 | ||||||
| HGNC | 17869 | ||||||
| OMIM | 604417 | ||||||
| RefSeq | NM_014423 | ||||||
| UniProt | Q9UHB7 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q31 | ||||||
| |||||||
Because it apparently interacts with the species-specific human co-factor (P-TEFb) for HIV-1 transcription, and because it can repress HIV-1 replication, MCEF (also known as AFF4 or AF5q31) may have future therapeutic uses.[1]
MCEF was originally cloned and named by Mario Clemente Estable of Ryerson University, while he was a post-doctoral fellow in the laboratory of Robert G. Roeder, at the Rockefeller University.
See also
editReferences
edit- ^ Estable M, Naghavi M, Kato H, Xiao H, Qin J, Vahlne A, Roeder R (2002). "MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein". J Biomed Sci. 9 (3): 234–245. doi:10.1007/BF02256070. PMID 12065898.
- Niedzielski MF, Hopewell R, Ismail Z, Estable MC (2007). "MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription". Int J Biol Sci. 3 (4): 225–236. doi:10.7150/ijbs.3.225. PMC 1820876. PMID 17389929.
- MCEF+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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