Alkylglycerone phosphate synthase (EC 2.5.1.26, alkyldihydroxyacetonephosphate synthase, alkyldihydroxyacetone phosphate synthetase, alkyl DHAP synthetase, alkyl-DHAP, dihydroxyacetone-phosphate acyltransferase, DHAP-AT) is an enzyme associated with Type 3 Rhizomelic chondrodysplasia punctata.[1][2] This enzyme catalyses the following chemical reaction
| alkylglycerone-phosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.26 | ||||||||
| CAS no. | 64060-42-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| alkylglycerone phosphate synthase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | AGPS | ||||||
| NCBI gene | 8540 | ||||||
| HGNC | 327 | ||||||
| OMIM | 603051 | ||||||
| RefSeq | NM_003659 | ||||||
| UniProt | O00116 | ||||||
| Other data | |||||||
| EC number | 2.5.1.26 | ||||||
| Locus | Chr. 2 q31 | ||||||
| |||||||
- 1-acyl-glycerone 3-phosphate + a long-chain alcohol an alkyl-glycerone 3-phosphate + a long-chain acid anion
References
edit- ^ Brown AJ, Snyder F (August 1982). "Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism". The Journal of Biological Chemistry. 257 (15): 8835–9. doi:10.1016/S0021-9258(18)34205-4. PMID 7096336.
- ^ Wykle RL, Plantadosi C, Snyder F (May 1972). "The role of acyldihydroxyacetone phosphate, reduced nicotinamide adenine dinucleotide, and reduced nicotinamide adenine dinucleotide phosphate in the biosynthesis of O-alkyl glycerolipids by microsomal enzymes of Ehrlich ascites tumor". The Journal of Biological Chemistry. 247 (9): 2944–8. doi:10.1016/S0021-9258(19)45301-5. PMID 4401994.
External links
edit- Alkylglycerone-phosphate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
