Aquaporin-8

Aquaporin-8 is a protein that in humans is encoded by the AQP8 gene.

AQP8
Identifiers
Aliases	AQP8, AQP-8, aquaporin 8
External IDs	OMIM: 603750; MGI: 1195271; HomoloGene: 68166; GeneCards: AQP8; OMA:AQP8 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p12.1 Start 25,215,731 bp End 25,228,932 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 F3|7 67.42 cM Start 123,061,514 bp End 123,067,227 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon body of pancreas mucosa of ileum rectum mucosa of sigmoid colon testicle pancreatic epithelial cell epithelium of colon islet of Langerhans cerebellar hemisphere Top expressed in left colon left lobe of liver lacrimal gland spermatocyte blastocyst yolk sac embryo parotid gland seminiferous tubule spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function water channel activity channel activity Cellular component integral component of membrane plasma membrane apical part of cell integral component of plasma membrane membrane mitochondrion mitochondrial membranes Biological process ion transmembrane transport cellular response to cAMP water transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 343 11833 Ensembl ENSG00000103375 ENSMUSG00000030762 UniProt O94778 P56404 RefSeq (mRNA) NM_001169 NM_001109045 NM_007474 RefSeq (protein) NP_001160 NP_001102515 NP_031500 Location (UCSC) Chr 16: 25.22 – 25.23 Mb Chr 7: 123.06 – 123.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Aquaporin-8 (AQP-8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-8 mRNA is found in pancreas and colon but not other tissues.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Harrington DJ, Adachi K, Royer WE (1997). "The high resolution crystal structure of deoxyhemoglobin S". J. Mol. Biol. 272 (3): 398–407. doi:10.1006/jmbi.1997.1253. PMID 9325099.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Fischer H, Stenling R, Rubio C, Lindblom A (2003). "Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors". BMC Physiol. 1: 1. doi:10.1186/1472-6793-1-1. PMC 32180. PMID 11231887.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Wang S, Kallichanda N, Song W, et al. (2001). "Expression of aquaporin-8 in human placenta and chorioamniotic membranes: evidence of molecular mechanism for intramembranous amniotic fluid resorption". Am. J. Obstet. Gynecol. 185 (5): 1226–31. doi:10.1067/mob.2001.117971. PMID 11717661.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang S, Chen J, Au KT, Ross MG (2003). "Expression of aquaporin 8 and its up-regulation by cyclic adenosine monophosphate in human WISH cells". Am. J. Obstet. Gynecol. 188 (4): 997–1001. doi:10.1067/mob.2003.214. PMID 12712100.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zahn A, Moehle C, Langmann T, et al. (2007). "Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis". World J. Gastroenterol. 13 (11): 1687–95. doi:10.3748/wjg.v13.i11.1687. PMC 4146947. PMID 17461471.

External links

• AQP8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human AQP8 genome location and AQP8 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.