ARID4B

AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.

ARID4B
Identifiers
Aliases	ARID4B, BCAA, BRCAA1, RBBP1L1, RBP1L1, SAP180, AT-rich interaction domain 4B
External IDs	OMIM: 609696; MGI: 2137512; HomoloGene: 12847; GeneCards: ARID4B; OMA:ARID4B - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.3 Start 235,131,634 bp End 235,328,219 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 A1|13 5.29 cM Start 14,237,817 bp End 14,374,188 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus sperm parietal pleura visceral pleura epithelium of nasopharynx tibia Achilles tendon germinal epithelium sural nerve buccal mucosa cell Top expressed in tail of embryo ascending aorta aortic valve medullary collecting duct supraoptic nucleus genital tubercle cumulus cell trigeminal ganglion ganglionic eminence blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding histone deacetylase activity molecular function DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleoplasm nucleus cellular component Biological process regulation of gene expression by genetic imprinting regulation of transcription, DNA-templated establishment of Sertoli cell barrier regulation of transcription by RNA polymerase II histone H4-K20 trimethylation transcription, DNA-templated histone H3-K9 trimethylation spermatogenesis positive regulation of transcription by RNA polymerase II histone deacetylation biological process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51742 94246 Ensembl ENSG00000054267 ENSMUSG00000039219 UniProt Q4LE39 A2CG63 RefSeq (mRNA) NM_001206794 NM_016374 NM_031371 NM_194262 NM_198122 RefSeq (protein) NP_001193723 NP_057458 NP_112739 NP_919238 NP_937755 Location (UCSC) Chr 1: 235.13 – 235.33 Mb Chr 13: 14.24 – 14.37 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.

External links

• Human ARID4B genome location and ARID4B gene details page in the UCSC Genome Browser.

Further reading

• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease". J. Cell Biol. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMC 2173089. PMID 12446740.
• Fleischer TC, Yun UJ, Ayer DE (2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Mol. Cell. Biol. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
• Cui D, Jin G, Gao T, Sun T, Tian F, Estrada GG, Gao H, Sarai A (2004). "Characterization of BRCAA1 and its novel antigen epitope identification". Cancer Epidemiol. Biomarkers Prev. 13 (7): 1136–45. doi:10.1158/1055-9965.1136.13.7. PMID 15247124. S2CID 28408982.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.