Asporin

Asporin is a protein that in humans is encoded by the ASPN gene.

ASPN
Identifiers
Aliases	ASPN, OS3, PLAP-1, PLAP1, SLRR1C, asporin, Asporin
External IDs	OMIM: 608135; MGI: 1913945; HomoloGene: 32357; GeneCards: ASPN; OMA:ASPN - orthologs
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A5 Start 49,697,919 bp End 49,721,041 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint periodontal fiber Achilles tendon saphenous vein visceral pleura right coronary artery ascending aorta vena cava gallbladder left coronary artery Top expressed in body of femur calvaria dermis intercostal muscle umbilical cord skin of external ear efferent ductule soleus muscle lumbar spinal ganglion ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein kinase inhibitor activity collagen binding extracellular matrix structural constituent conferring compression resistance Cellular component cytoplasm extracellular matrix extracellular region collagen-containing extracellular matrix Biological process bone mineralization biomineral tissue development negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of tooth mineralization negative regulation of protein kinase activity cytokine-mediated signaling pathway negative regulation of receptor signaling pathway via JAK-STAT Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54829 66695 Ensembl n/a ENSMUSG00000021388 UniProt Q9BXN1 Q99MQ4 RefSeq (mRNA) NM_017680 NM_001193335 NM_001172481 NM_025711 RefSeq (protein) NP_001180264 NP_060150 NP_001165952 NP_079987 Location (UCSC) n/a Chr 13: 49.7 – 49.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the overall similarity to decorin (MIM 125255) (Lorenzo et al., 2001).

External links

• Human ASPN genome location and ASPN gene details page in the UCSC Genome Browser.

Further reading

• Lorenzo P, Aspberg A, Onnerfjord P, Bayliss MT, Neame PJ, Heinegard D (Apr 2001). "Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan". The Journal of Biological Chemistry. 276 (15): 12201–11. doi:10.1074/jbc.M010932200. PMID 11152692.
• Henry SP, Takanosu M, Boyd TC, Mayne PM, Eberspaecher H, Zhou W, de Crombrugghe B, Hook M, Mayne R (Apr 2001). "Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family". The Journal of Biological Chemistry. 276 (15): 12212–21. doi:10.1074/jbc.M011290200. PMID 11152695.
• Yamada S, Murakami S, Matoba R, Ozawa Y, Yokokoji T, Nakahira Y, Ikezawa K, Takayama S, Matsubara K, Okada H (Sep 2001). "Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene". Gene. 275 (2): 279–86. doi:10.1016/S0378-1119(01)00683-7. PMID 11587855.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida A, Nakamura K, Notoya K, Nakamura Y, Ikegawa S (Feb 2005). "An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis". Nature Genetics. 37 (2): 138–44. doi:10.1038/ng1496. PMID 15640800. S2CID 6771016.
• Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez-Reino JJ, Gonzalez A (2006). "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians". Arthritis Research & Therapy. 8 (3): R55. doi:10.1186/ar1920. PMC 1526645. PMID 16542493.
• Yamada S, Ozawa Y, Tomoeda M, Matoba R, Matsubara K, Murakami S (May 2006). "Regulation of PLAP-1 expression in periodontal ligament cells". Journal of Dental Research. 85 (5): 447–51. doi:10.1177/154405910608500510. PMID 16632759. S2CID 40160016.
• Jiang Q, Shi D, Yi L, Ikegawa S, Wang Y, Nakamura T, Qiao D, Liu C, Dai J (2007). "Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese". Journal of Human Genetics. 51 (12): 1068–72. doi:10.1007/s10038-006-0065-6. PMID 17024313.
• Nakamura T, Shi D, Tzetis M, Rodriguez-Lopez J, Miyamoto Y, Tsezou A, Gonzalez A, Jiang Q, Kamatani N, Loughlin J, Ikegawa S (Jul 2007). "Meta-analysis of association between the ASPN D-repeat and osteoarthritis". Human Molecular Genetics. 16 (14): 1676–81. doi:10.1093/hmg/ddm115. PMID 17517696.
• Shi D, Nakamura T, Dai J, Yi L, Qin J, Chen D, Xu Z, Wang Y, Ikegawa S, Jiang Q (2007). "Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population". Journal of Human Genetics. 52 (8): 664–7. doi:10.1007/s10038-007-0166-x. PMID 17603749.
• Kou I, Nakajima M, Ikegawa S (Nov 2007). "Expression and regulation of the osteoarthritis-associated protein asporin". The Journal of Biological Chemistry. 282 (44): 32193–9. doi:10.1074/jbc.M706262200. PMID 17804408.
• Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S (Nov 2007). "Mechanisms for asporin function and regulation in articular cartilage". The Journal of Biological Chemistry. 282 (44): 32185–92. doi:10.1074/jbc.M700522200. PMID 17827158.