ATP5PO

ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5PO gene.

ATP5PO
Identifiers
Aliases	ATP5PO, ATPO, OSCP, HMC08D05, ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit, ATP synthase peripheral stalk subunit OSCP, ATP5O
External IDs	OMIM: 600828; MGI: 106341; HomoloGene: 1283; GeneCards: ATP5PO; OMA:ATP5PO - orthologs
Gene location (Human) Chr. Chromosome 21 (human) Band 21q22.11 Start 33,903,453 bp End 33,915,814 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C4 Start 91,722,102 bp End 91,728,575 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ventricle apex of heart right auricle ganglionic eminence gastrocnemius muscle mucosa of transverse colon muscle of thigh rectum dorsolateral prefrontal cortex body of stomach Top expressed in endocardial cushion atrioventricular valve myocardium of ventricle muscle of thigh intercostal muscle yolk sac soleus muscle spermatocyte right kidney atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function proton-transporting ATP synthase activity, rotational mechanism transmembrane transporter activity transporter activity ATPase activity protein binding Cellular component mitochondrial proton-transporting ATP synthase complex membrane plasma membrane mitochondrion mitochondrial inner membrane extracellular exosome nucleus extracellular matrix Biological process mitochondrial ATP synthesis coupled proton transport ion transport ATP synthesis coupled proton transport ATP biosynthetic process cristae formation transport proton transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 539 28080 Ensembl ENSG00000241837 ENSMUSG00000022956 UniProt P48047 Q9DB20 RefSeq (mRNA) NM_001697 NM_138597 RefSeq (protein) NP_001688 NP_613063 Location (UCSC) Chr 21: 33.9 – 33.92 Mb Chr 16: 91.72 – 91.73 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance.

External links

• Human ATP5PO genome location and ATP5PO gene details page in the UCSC Genome Browser.

Further reading

• Chen H, Morris MA, Rossier C, et al. (1996). "Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2". Genomics. 28 (3): 470–6. doi:10.1006/geno.1995.1176. PMID 7490082.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Aggeler R, Coons J, Taylor SW, et al. (2002). "A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies". J. Biol. Chem. 277 (37): 33906–12. doi:10.1074/jbc.M204538200. PMID 12110673.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Johnson KM, Chen X, Boitano A, et al. (2005). "Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423". Chem. Biol. 12 (4): 485–96. doi:10.1016/j.chembiol.2005.02.012. PMID 15850986.