Alexander or Alex Santos may refer to:
- Alex Santos (newscaster) (born 1970), Filipino newscaster and reporter
- Alexandro da Silva Santos, Brazilian striker
- Alexandre José Maria dos Santos (1924–2021), Mozambican Roman Catholic cardinal
- Alessandro Santos (born 1977), Brazilian-born Japanese footballer, known as Alex
- Alex dos Santos (footballer) (born 1981), Brazilian football defender
- Alex Santos (footballer) (born 1993), Brazilian footballer
- Alex Santos (baseball)