Alpha-1B adrenergic receptor

ADRA1B
Identifiers
Aliases	ADRA1B, ADRA1, ALPHA1BAR, adrenoceptor alpha 1B
External IDs	OMIM: 104220; MGI: 104774; HomoloGene: 55477; GeneCards: ADRA1B; OMA:ADRA1B - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	159,973,012 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	43,792,037 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; right lung;
	Top expressed in
	left lobe of liver; ; superior frontal gyrus; ; right ventricle; ; primary visual cortex; ; lateral geniculate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; medial dorsal nucleus; ; nucleus of stria terminalis; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; adrenergic receptor activity; protein heterodimerization activity; alpha1-adrenergic receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; nucleus; nuclear membrane; plasma membrane; cytoplasm; caveola;
Biological process	regulation of muscle contraction; intracellular signal transduction; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; glucose homeostasis; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; cell-cell signaling; multicellular organism development; adenylate cyclase-activating adrenergic receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; regulation of vasoconstriction; positive regulation of vasoconstriction; regulation of cardiac muscle contraction; cell population proliferation; positive regulation of smooth muscle contraction; positive regulation of MAPK cascade; signal transduction; G protein-coupled receptor signaling pathway; neuron-glial cell signaling;
	Sources:Amigo / QuickGO
Orthologs
	147
	11548
	ENSG00000170214
	ENSMUSG00000050541
	P35368
	P97717
	NM_000679
	NM_001284380; NM_001284381; NM_007416
	NP_000670
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

The alpha-1B adrenergic receptor (α_1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.^[5] The crystal structure of the α_1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.^[6]

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.^[5]

Ligands

Antagonists

Interactions

Alpha-1B adrenergic receptor has been shown to interact with AP2M1.^[8] A role in regulation of dopaminergic neurotransmission has also been suggested.^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170214 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050541 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor".
^ Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PR, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A (January 2022). "Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition". Nature Communications. 13 (1): 382. Bibcode:2022NatCo..13..382D. doi:10.1038/s41467-021-27911-3. PMC 8770593. PMID 35046410.
^ Mizusawa H, Hedlund P, Sjunnesson J, Brioni JD, Sullivan JP, Andersson KE (2002). "Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist". Br. J. Pharmacol. 136 (5): 701–8. doi:10.1038/sj.bjp.0704773. PMC 1573401. PMID 12086979.
^ Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S (May 2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451.
^ Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP (April 2002). "Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates". J. Neurosci. 22 (7): 2873–84. doi:10.1523/jneurosci.22-07-02873.2002. PMC 6758308. PMID 11923452.
^ Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP (December 2004). "5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants". Eur. J. Neurosci. 20 (11): 3073–84. doi:10.1111/j.1460-9568.2004.03805.x. PMID 15579162. S2CID 25138763.

External links

Human ADRA1B genome location and ADRA1B gene details page in the UCSC Genome Browser.

Ramarao CS, Denker JM, Perez DM, et al. (1992). "Genomic organization and expression of the human alpha 1B-adrenergic receptor". J. Biol. Chem. 267 (30): 21936–45. doi:10.1016/S0021-9258(19)36703-1. PMID 1328250.
Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S (1992). "G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity" (PDF). Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11354–8. doi:10.1073/pnas.88.24.11354. PMC 53133. PMID 1662393.
Lomasney JW, Cotecchia S, Lorenz W, et al. (1991). "Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5". J. Biol. Chem. 266 (10): 6365–9. doi:10.1016/S0021-9258(18)38126-2. PMID 1706716.
Yang-Feng TL, Xue FY, Zhong WW, et al. (1990). "Chromosomal organization of adrenergic receptor genes". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516–20. Bibcode:1990PNAS...87.1516Y. doi:10.1073/pnas.87.4.1516. PMC 53506. PMID 2154750.
Schwinn DA, Johnston GI, Page SO, et al. (1995). "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues". J. Pharmacol. Exp. Ther. 272 (1): 134–42. PMID 7815325.
Weinberg DH, Trivedi P, Tan CP, et al. (1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem. Biophys. Res. Commun. 201 (3): 1296–304. doi:10.1006/bbrc.1994.1845. PMID 8024574.
Forray C, Bard JA, Wetzel JM, et al. (1994). "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype". Mol. Pharmacol. 45 (4): 703–8. PMID 8183249.
Diviani D, Lattion AL, Larbi N, et al. (1996). "Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 271 (9): 5049–58. doi:10.1074/jbc.271.9.5049. PMID 8617782.
Diviani D, Lattion AL, Cotecchia S (1997). "Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor". J. Biol. Chem. 272 (45): 28712–9. doi:10.1074/jbc.272.45.28712. PMID 9353340.
Qian A, Wang W, Sanborn BM (1998). "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11)". Cell. Signal. 10 (2): 101–5. doi:10.1016/S0898-6568(97)00097-1. PMID 9481484.
Sasaguri T, Teruya H, Ishida A, et al. (2000). "Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells". Biochem. Biophys. Res. Commun. 268 (1): 25–30. doi:10.1006/bbrc.1999.2066. PMID 10652206.
Minneman KP, Lee D, Zhong H, et al. (2000). "Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes". J. Neurochem. 74 (6): 2392–400. doi:10.1046/j.1471-4159.2000.0742392.x. PMID 10820200. S2CID 16002509.
Shibata K, Katsuma S, Koshimizu T, et al. (2003). "alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1". J. Biol. Chem. 278 (1): 672–8. doi:10.1074/jbc.M201375200. PMID 12409310.
Diviani D, Lattion AL, Abuin L, et al. (2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451.
Gonzalez-Cabrera PJ, Gaivin RJ, Yun J, et al. (2003). "Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130". Mol. Pharmacol. 63 (5): 1104–16. doi:10.1124/mol.63.5.1104. PMID 12695539. S2CID 10868191.
Pupo AS, Minneman KP (2004). "Specific interactions between gC1qR and alpha1-adrenoceptor subtypes". J. Recept. Signal Transduct. Res. 23 (2–3): 185–95. doi:10.1081/RRS-120025200. PMID 14626446. S2CID 29600903.
Hague C, Uberti MA, Chen Z, et al. (2004). "Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors". J. Biol. Chem. 279 (15): 15541–9. doi:10.1074/jbc.M314014200. PMID 14736874.
Kang SK, Yi KS, Kwon NS, et al. (2004). "Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits". J. Biol. Chem. 279 (35): 36593–600. doi:10.1074/jbc.M402084200. PMID 15220331.
Gonzalez-Cabrera PJ, Shi T, Yun J, et al. (2004). "Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes". Endocrinology. 145 (11): 5157–67. doi:10.1210/en.2004-0728. PMID 15297446.
Zhang T, Xu Q, Chen FR, et al. (2005). "Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors". Acta Pharmacol. Sin. 25 (11): 1471–8. PMID 15525470.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170214 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050541 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor".

[pmid=35046410-6] Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PR, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A (January 2022). "Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition". Nature Communications. 13 (1): 382. Bibcode:2022NatCo..13..382D. doi:10.1038/s41467-021-27911-3. PMC 8770593. PMID 35046410.

[pmid12086979-7] Mizusawa H, Hedlund P, Sjunnesson J, Brioni JD, Sullivan JP, Andersson KE (2002). "Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist". Br. J. Pharmacol. 136 (5): 701–8. doi:10.1038/sj.bjp.0704773. PMC 1573401. PMID 12086979.

[pmid12644451-8] Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S (May 2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451.

[pmid11923452-9] Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP (April 2002). "Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates". J. Neurosci. 22 (7): 2873–84. doi:10.1523/jneurosci.22-07-02873.2002. PMC 6758308. PMID 11923452.

[pmid15579162-10] Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP (December 2004). "5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants". Eur. J. Neurosci. 20 (11): 3073–84. doi:10.1111/j.1460-9568.2004.03805.x. PMID 15579162. S2CID 25138763.

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