α-D2PV

α-D2PV
Legal status
Legal status	DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B;
Identifiers
	IUPAC name 1,2-diphenyl-2-(1-pyrrolidinyl)ethanone;
CAS Number	27590-61-0;
PubChem CID	33957;
ChemSpider	31300;
UNII	5EB3HC2KW8;
Chemical and physical data
Formula	C18H19N
Molar mass	249.357 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCN(C1)C(C2=CC=CC=C2)C(=O)C3=CC=CC=C3;
	InChI InChI=1S/C18H19NO/c20-18(16-11-5-2-6-12-16)17(19-13-7-8-14-19)15-9-3-1-4-10-15/h1-6,9-12,17H,7-8,13-14H2; Key:GQCCTZGWWWUYLS-UHFFFAOYSA-N;

α-D2PV (DPPE) is a substituted cathinone derivative which has been sold as a designer drug. It was invented in the 1950s,^[1] and first identified by forensic laboratories as a designer drug in 2020, though anecdotal reports suggest it may have emerged earlier than this. It is similar in structure to the potent designer stimulant drug alpha-PVP but with the propyl side chain replaced by a phenyl ring, and while it is less potent than alpha-PVP itself, Alpha-D2PV is still a reasonably potent stimulant and has been known to cause poisoning when misrepresented as less potent drugs such as MDMA. While it is also similar in structure to the dissociative drug diphenidine, Alpha-D2PV appears to produce only stimulant effects.^[2]^[3]^[4]

References

^ US 2773069, Heinzelman RV, Aspergren BD, "1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings", issued 4 December 1956, assigned to Pharmacia and Upjohn Co.
^ Kuropka P, Zawadzki M, Szpot P (2023). "A review of synthetic cathinones emerging in recent years (2019-2022)". Forensic Toxicology. 41 (1): 25–46. doi:10.1007/s11419-022-00639-5. PMC 9476408. PMID 36124107.
^ Puljević C, Tscharke B, Wessel EL, Francis C, Verhagen R, O'Brien JW, et al. (April 2024). "Characterising differences between self-reported and wastewater-identified drug use at two consecutive years of an Australian music festival". The Science of the Total Environment. 921: 170934. doi:10.1016/j.scitotenv.2024.170934. PMID 38360330.
^ Wood MR, Bernal I, Lalancette RA (April 2024). "Crystal structure and analytical profile of 1,2-diphenyl-2-pyrrolidin-1-ylethanone hydrochloride or 'α-D2PV': a synthetic cathinone seized by law enforcement, along with its diluent sugar, myo-inositol". Acta Crystallographica Section C. 80 (4): 91–97. doi:10.1107/S2053229624000561. PMC 10996188. PMID 38441142.

[1] US 2773069, Heinzelman RV, Aspergren BD, "1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings", issued 4 December 1956, assigned to Pharmacia and Upjohn Co.

[pmid36124107-2] Kuropka P, Zawadzki M, Szpot P (2023). "A review of synthetic cathinones emerging in recent years (2019-2022)". Forensic Toxicology. 41 (1): 25–46. doi:10.1007/s11419-022-00639-5. PMC 9476408. PMID 36124107.

[pmid38360330-3] Puljević C, Tscharke B, Wessel EL, Francis C, Verhagen R, O'Brien JW, et al. (April 2024). "Characterising differences between self-reported and wastewater-identified drug use at two consecutive years of an Australian music festival". The Science of the Total Environment. 921: 170934. doi:10.1016/j.scitotenv.2024.170934. PMID 38360330.

[pmid38441142-4] Wood MR, Bernal I, Lalancette RA (April 2024). "Crystal structure and analytical profile of 1,2-diphenyl-2-pyrrolidin-1-ylethanone hydrochloride or 'α-D2PV': a synthetic cathinone seized by law enforcement, along with its diluent sugar, myo-inositol". Acta Crystallographica Section C. 80 (4): 91–97. doi:10.1107/S2053229624000561. PMC 10996188. PMID 38441142.

[1]

[2]

[3]

[4]

α-D2PV

See also

References