Amie Kathleen Boal is an American chemist. She is an associate professor of chemistry, biochemistry, and molecular biology at Pennsylvania State University. In 2020, Boal was the recipient of the Pfizer Award in Enzyme Chemistry from the American Chemical Society.
Amie Boal | |
|---|---|
| Born | Amie Kathleen Boal Portland, Oregon, U.S. |
| Awards | Pfizer Award in Enzyme Chemistry Camille Dreyfus Teacher-Scholar Awards |
| Academic background | |
| Education | BA, Chemistry, 2002, Pomona College PhD, Chemistry, 2008, California Institute of Technology |
| Thesis | DNA-Mediated Charge Transport in DNA Repair (2008) |
| Doctoral advisor | Jacqueline Barton |
| Academic work | |
| Institutions | Pennsylvania State University Northwestern University |
Early life and education
editBoal is a native of Portland, Oregon. She earned her Bachelor of Arts degree in chemistry from Pomona College and her PhD in the same subject from the California Institute of Technology.[1] Boal wrote her thesis, DNA-Mediated Charge Transport in DNA Repair, which won the Herbert Newby McCoy Award, in 2008 under the guidance of Jacqueline Barton.[2]
Following this, Boal accepted a post-doctoral position in Amy Rosenzweig's laboratory at Northwestern University where she studied interactions between platinum-based anticancer therapeutics and human copper homeostasis proteins.[1] During her post-doctoral fellowship, Boal was awarded a National Institutes of Health (NIH) Pathway to Independence Award and an NIH Ruth L. Kirschstein National Research Service Award.[3]
Career
editBoal remained at Northwestern until 2013 when she joined the Departments of Chemistry and of Biochemistry and Molecular Biology at Pennsylvania State University. Her research focused on understanding the structural basis for mechanism and function in diverse families of metalloenzymes.[4] Upon joining the faculty, she was named a Searle Scholar to support her independent research into understanding how microorganisms acquire and use metal ions.[3] Following this, she collaborated with Squire Booker to determine the three-dimensional structure of the RlmN protein from the bacterium.[5] As a result of her collaborative research, Boal was the recipient of a Maximizing Investigators' Research Award for Early Stage Investigators at the NIH.[6]
Prior to her promotion to associate professor, Boal was the senior author of a study that showed that a new subclass of ribonucleotide reductase (RNR) was able to use a modified amino acid instead of a metal ion as the oxidizing agent.[7] In the same year, she was recognized with a Camille Dreyfus Teacher-Scholar Award for being a young chemist who has "created an outstanding independent body of scholarship, and are deeply committed to education."[8]
Boal and her research team later solved an x-ray crystal structure of SznF, showing that the protein contains two different active sites. As a result, she teamed up with Emily Balskus from Harvard University to explore how the bacterium that lives in soil produces streptozotocin.[9] Prior to the start of the 2019–20 academic year, Boal was promoted to the rank of associate professor.[10]
During the COVID-19 pandemic, Boal was the recipient of the Pfizer Award in Enzyme Chemistry from the American Chemical Society.[6]
Awards
edit- 2020 – Pfizer Award in Enzyme Chemistry
- 2018 – Camille Dreyfus Teacher-Scholar Awards
- 2014 - Searle Scholars Program[11]
- 2012 – NIH Pathway to Independence Award
References
edit- ^ a b Boal, Amie K.; Rosenzweig, Amy C. (October 2009). "Structural Biology of Copper Trafficking". Chemical Reviews. 109 (10): 4760–4779. doi:10.1021/cr900104z. PMC 2768115. PMID 19824702.
- ^ Boal, Amie Kathleen (2008). DNA-Mediated Charge Transport in DNA Repair (Thesis). Caltech Library. doi:10.7907/CMWB-6C92. Retrieved June 15, 2021.
- ^ a b "Boal named 2014 Searle Scholar". Penn State. July 14, 2014. Retrieved June 15, 2021.
- ^ "Inorganic Chemistry Seminar: Amie K. Boal, Pennsylvania State University". Stanford University. March 13, 2019. Retrieved June 15, 2021.
- ^ Sholtis, Sam (April 20, 2016). "Caught in the act: 3D structure of an RNA-modifying protein determined in action". Penn State. Retrieved June 15, 2021.
- ^ a b Landschoot, Marie (September 23, 2020). "Amie Boal honored with Pfizer Award in Enzyme Chemistry". Penn State. Retrieved June 15, 2021.
- ^ Sholtis, Sam (October 18, 2018). "Pathogens may evade immune response with metal-free enzyme". Penn State. Retrieved June 15, 2021.
- ^ "Amie Boal receives 2018 Camille Dreyfus Teacher-Scholar Award". Penn State. May 8, 2018. Retrieved June 15, 2021.
- ^ Landschoot, Maria (February 25, 2019). "Boal Group Teams up with Harvard to Study How Bacteria Produces a Compound Used to Treat Cancer". Penn State. Retrieved June 15, 2021.
- ^ "Penn State promotions in academic rank, effective July 1, 2019". Penn State. June 20, 2019. Retrieved June 15, 2021.
- ^ "Searle Scholars Program". Scholar Profile Amie K. Boal. Archived from the original on September 5, 2015. Retrieved 2 June 2023.