Andrew Hughes may refer to:
- Andrew Hughes (actor) (1908–1996), Turkish-born actor
- Andrew Hughes (footballer, born 1978), English footballer
- Andrew Hughes (footballer, born 1992), Welsh footballer
- Andrew Hughes (musicologist); see List of University of Toronto people
- Andrew Hughes (police officer) (1956–2018), Fijian Commissioner of Police
- Andrew Hughes (politician) (1902–1996), Australian politician
- Andrew Hughes (rugby union) (born 1995), English rugby union player
- Andy Hughes (1965–2009), music producer