Andrew Mackay may refer to:
- Andrew Mackay (mathematician) (1760–1809), Scottish mathematician
- Andrew William McKay (art dealer) (died 1899), British art dealer
- Andrew MacKay (Canadian politician) (fl. 1908–1911), member of the Legislative Assembly of Ontario
- William Andrew MacKay (1929–2013), Canadian lawyer
- Andy Mackay (born 1946), English musician, founder of Roxy Music
- Andrew MacKay (born 1949), British Conservative politician
- Andrew Mackay (British Army officer), British Army major general
- Andrew Mackay (Australian politician), member of the Northern Territory Legislative Assembly from 2024
- Andy McKay (born 1980), New Zealand cricketer
- Andrew Mackay (swimmer) (born 1985), Olympic swimmer from the Cayman Islands