Anna Smith may refer to:
- Ann Bedsole (born 1930 as Anna Smith), American politician
- Anna Deavere Smith (born 1950), actress and academic
- Anna Nicole Smith (1967–2007), model and actress
- Anna Smith (cricketer) (born 1978), New Zealand cricketer
- Anna Smith (tennis) (born 1988), British tennis player
- Anna Smith (critic) (21st century), British film critic
- Anna Smith Strong
- Anna Tolman Smith (1840–1917), American educator