Pyruvate dehydrogenase (NADP+) EC 1.2.1.51 is an enzyme that should not be confused with Pyruvate dehydrogenase (acetyltransferase) EC 1.2.4.1.[1][2]
| Pyruvate dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.2.1.51 | ||||||||
| CAS no. | 93389-35-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
It catalyzes the following reaction:
- Pyruvate + Coenzyme A + NADP+ ⇒ acetyl-CoA + NADPH + H+ + CO2
References
edit- ^ Inui H, Miyatake K, Nakano Y, Kitaoka S (September 1984). "Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis". Journal of Biochemistry. 96 (3): 931–4. doi:10.1093/oxfordjournals.jbchem.a134913. PMID 6438078.
- ^ Inui H, Ono K, Miyatake K, Nakano Y, Kitaoka S (July 1987). "Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis". The Journal of Biological Chemistry. 262 (19): 9130–5. PMID 3110154.
Further reading
edit- Ctrnacta V, Ault JG, Stejskal F, Keithly JS (2006). "Localization of pyruvate:NADP+ oxidoreductase in sporozoites of Cryptosporidium parvum". The Journal of Eukaryotic Microbiology. 53 (4): 225–31. doi:10.1111/j.1550-7408.2006.00099.x. PMID 16872290.
- Inui H, Miyatake K, Nakano Y, Kitaoka S (March 1985). "The physiological role of oxygen-sensitive pyruvate dehydrogenase in mitochondrial fatty acid synthesis in Euglena gracilis". Archives of Biochemistry and Biophysics. 237 (2): 423–9. doi:10.1016/0003-9861(85)90295-4. PMID 3919646.
- Inui H, Miyatake K, Nakano Y, Kitaoka S (November 1989). "Pyruvate:NADP+ oxidoreductase from Euglena gracilis: the kinetic properties of the enzyme". Archives of Biochemistry and Biophysics. 274 (2): 434–42. doi:10.1016/0003-9861(89)90456-6. PMID 2508561.
- Inui H, Miyatake K, Nakano Y, Kitaoka S (August 1990). "Pyruvate:NADP+ oxidoreductase from Euglena gracilis: mechanism of O2-inactivation of the enzyme and its stability in the aerobe". Archives of Biochemistry and Biophysics. 280 (2): 292–8. doi:10.1016/0003-9861(90)90332-S. PMID 2114824.
- Inui H, Yamaji R, Saidoh H, Miyatake K, Nakano Y, Kitaoka S (April 1991). "Pyruvate:NADP+ oxidoreductase from Euglena gracilis: limited proteolysis of the enzyme with trypsin". Archives of Biochemistry and Biophysics. 286 (1): 270–6. doi:10.1016/0003-9861(91)90040-P. PMID 1910287.
- Lochmeyer, C.; Fuchs, G. (1990). "NADP+-specific 2-oxoglutarate dehydrogenase in denitrifying Pseudomonas species". Arch. Microbiol. 153 (3): 226–229. doi:10.1007/BF00249072.
- Nakazawa M, Inui H, Yamaji R, Yamamoto T, Takenaka S, Ueda M, Nakano Y, Miyatake K (August 2000). "The origin of pyruvate: NADP+ oxidoreductase in mitochondria of Euglena gracilis". FEBS Letters. 479 (3): 155–6. doi:10.1016/S0014-5793(00)01882-2. PMID 11023353.
- Nakazawa M, Takenaka S, Ueda M, Inui H, Nakano Y, Miyatake K (March 2003). "Pyruvate:NADP+ oxidoreductase is stabilized by its cofactor, thiamin pyrophosphate, in mitochondria of Euglena gracilis". Archives of Biochemistry and Biophysics. 411 (2): 183–8. doi:10.1016/S0003-9861(02)00749-X. PMID 12623066.
- Sawada K, Taki A, Yamakawa T, Seki M (November 2009). "Key role for transketolase activity in erythritol production by Trichosporonoides megachiliensis SN-G42". Journal of Bioscience and Bioengineering. 108 (5): 385–90. doi:10.1016/j.jbiosc.2009.05.008. PMID 19804861.
External links
edit- EC 1.2.1.51 IUBMB Enzyme Nomenclature at chem.qmul.ac.uk
- EC 1.2.1.51 - pyruvate dehydrogenase (NADP+) at Brenda-enzymes.org
- ENZYME entry: EC 1.2.1.51 at Enzyme.expasy.org
