Arias-Stella reaction

Arias-Stella reaction, also Arias-Stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue.^[1]

Arias-Stella reaction is due to progesterone primarily. Cytologically, it resembles a malignancy and, historically, it was misdiagnosed as endometrial cancer.^[1]

Significance

It is significant only because it can be misdiagnosed as a cancer. It may be seen in a completely normal pregnancy.

Diagnosis

It is characterized by nuclear enlargement and may also have any of the following: an irregular nuclear membrane, granular chromatin, centronuclear vacuolization, and pseudonuclear inclusions.^[1]

Five subtypes are recognized:^[1]

Minimal atypia.
Early secretory pattern.
Secretory or hypersecretory pattern.
Regenerative, proliferative or nonsecretory pattern.
Monstrous cell pattern.

History

It was first described by Javier Arias Stella, a Peruvian pathologist, in 1954.^[2]

References

^ ^a ^b ^c ^d Arias-Stella, J. (Jan 2002). "The Arias-Stella reaction: facts and fancies four decades after". Adv Anat Pathol. 9 (1): 12–23. doi:10.1097/00125480-200201000-00003. PMID 11756756. S2CID 26249687.
^ Arias-Stella, J. (Aug 1954). "Atypical endometrial changes associated with the presence of chorionic tissue". Arch Pathol. 58 (2): 112–28. PMID 13170908.

Bibliography

Textbook of Obstetrics by D.C. Dutta Page no. 180. ISBN 81-7381-142-3

[pmid11756756-1] Arias-Stella, J. (Jan 2002). "The Arias-Stella reaction: facts and fancies four decades after". Adv Anat Pathol. 9 (1): 12–23. doi:10.1097/00125480-200201000-00003. PMID 11756756. S2CID 26249687.

[pmid13170908-2] Arias-Stella, J. (Aug 1954). "Atypical endometrial changes associated with the presence of chorionic tissue". Arch Pathol. 58 (2): 112–28. PMID 13170908.

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