Asaf Khan (Urdu: آصف خان) may refer to several members of the nobility of the Mughal Dynasty of India:
- Asaf Khan I, or Khwaja Abdul Majid, during the reign of Akbar
- Abu'l-Hasan Asaf Khan (1569–1641), Grand Vizier of the Mughal emperor Shah Jahan
Asaf Khan (Urdu: آصف خان) may refer to several members of the nobility of the Mughal Dynasty of India: