The Autovía A-381 is a local autovía in Andalusia, Spain. It is 88 km (55 miles) long and runs from the Autopista AP-4 at Jerez de la Frontera to the Autovía A-7 at Los Barrios, near Algeciras. Built between 2004 and 2006, it runs parallel to the former C-440 road, including through Los Alcornocales Natural Park.
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