Ayre is a surname. Notable people with the surname include:

  • Sir Amos Ayre (1885–1952), English shipbuilder and high-ranking Admiralty official
  • Bella Ayre (born 1998), Australian rules footballer
  • Billy Ayre (1952–2002), English footballer
  • Bobby Ayre (1932–2018), English former footballer
  • Calvin Ayre (born 1961), Canadian founder of the Bodog online gaming and entertainment brand
  • Charles R. Ayre (1819–1889), Newfoundland merchant and politician
  • Colin Ayre (born 1956), English former footballer
  • Garry Ayre (born 1953), Canadian former soccer player
  • Jack Ayre (1894–1977), Canadian entertainer
  • James S. Ayre (1881–1953), businessman and political figure in Newfoundland
  • John B. Ayre (1850–1915), merchant and political figure in Newfoundland, son of Charles Ayre
  • Keegan Ayre (born 1988), Canadian soccer player
  • Kristian Ayre (born 1977), Canadian actor
  • Lewis H.M. Ayre (1914–1985), Canadian businessman
  • Richard James Ayre, English journalist
  • Sanjay Ayre (born 1980), Jamaican sprinter
  • William Ayre (1782 or 1783–1855), Canadian educator