Azucena is a Spanish surname and a feminine given name.
Notable people with the surname include:
- Cesario Azucena (1938–2021), Filipino lawyer, professor, management consultant, and author
- Maya Azucena, American singer-songwriter and cultural ambassador
Notable people with the given name include:
- Azucena Arbeleche (born 1970), Uruguayan economist, professor, and civil servant
- Azucena Berruti (born 1929), Uruguayan politician
- Azucena Grajo Uranza (1929–2012), Filipino novelist
- Azucena Villaflor (1924–1977), Argentine social activist
Fictional characters include:
- Azucena (gypsy), a character in the opera Il Trovatore
- Azucena Milagros Ortiz Castillo, a character in the video game series Tekken