VTCN1

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.

VTCN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GOS
Identifiers
Aliases	VTCN1, B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1, V-set domain containing T cell activation inhibitor 1, V-set domain containing T-cell activation inhibitor 1
External IDs	OMIM: 608162; MGI: 3039619; HomoloGene: 11627; GeneCards: VTCN1; OMA:VTCN1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p13.1-p12 Start 117,143,587 bp End 117,210,960 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.2 Start 100,732,775 bp End 100,804,238 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva epithelium of lactiferous gland lactiferous duct hair follicle right uterine tube islet of Langerhans nasal epithelium body of pancreas olfactory zone of nasal mucosa secondary oocyte Top expressed in blastocyst morula spermatid uterus lip ascending aorta aortic valve cervix esophagus proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding molecular function Cellular component integral component of membrane plasma membrane membrane external side of plasma membrane Biological process adaptive immune response positive regulation of T cell proliferation response to protozoan immune system process negative regulation of T cell proliferation negative regulation of apoptotic process negative regulation of T cell activation regulation of immune response T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79679 242122 Ensembl ENSG00000134258 ENSMUSG00000051076 UniProt Q7Z7D3 Q7TSP5 RefSeq (mRNA) NM_001253849 NM_001253850 NM_024626 NM_178594 RefSeq (protein) NP_001240778 NP_001240779 NP_078902 NP_848709 Location (UCSC) Chr 1: 117.14 – 117.21 Mb Chr 3: 100.73 – 100.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]

B7-H4 is an immune checkpoint molecule.

See also

• B7 (protein)

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM (July 2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Nature Immunology. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776. S2CID 11943145.
• Zang X, Loke P, Kim J, Murphy K, Waitz R, Allison JP (September 2003). "B7x: a widely expressed B7 family member that inhibits T cell activation". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10388–92. Bibcode:2003PNAS..10010388Z. doi:10.1073/pnas.1434299100. PMC 193571. PMID 12920180.
• Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L (November 2003). "Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family". Journal of Immunology. 171 (9): 4650–4. doi:10.4049/jimmunol.171.9.4650. PMID 14568939.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Salceda S, Tang T, Kmet M, Munteanu A, Ghosh M, Macina R, Liu W, Pilkington G, Papkoff J (May 2005). "The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation". Experimental Cell Research. 306 (1): 128–41. doi:10.1016/j.yexcr.2005.01.018. PMID 15878339.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W (April 2006). "B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma". The Journal of Experimental Medicine. 203 (4): 871–81. doi:10.1084/jem.20050930. PMC 2118300. PMID 16606666.
• Kryczek I, Wei S, Zou L, Zhu G, Mottram P, Xu H, Chen L, Zou W (July 2006). "Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells". Journal of Immunology. 177 (1): 40–4. doi:10.4049/jimmunol.177.1.40. PMID 16785496. S2CID 922578.
• Krambeck AE, Thompson RH, Dong H, Lohse CM, Park ES, Kuntz SM, Leibovich BC, Blute ML, Cheville JC, Kwon ED (July 2006). "B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival". Proceedings of the National Academy of Sciences of the United States of America. 103 (27): 10391–6. Bibcode:2006PNAS..10310391K. doi:10.1073/pnas.0600937103. PMC 1502468. PMID 16798883.
• Chen Y, Yang C, Xie Z, Zou L, Ruan Z, Zhang X, Tang Y, Fei L, Jia Z, Wu Y (December 2006). "Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells". Kidney International. 70 (12): 2092–9. doi:10.1038/sj.ki.5001867. PMID 17051145.
• Simon I, Katsaros D, Rigault de la Longrais I, Massobrio M, Scorilas A, Kim NW, Sarno MJ, Wolfert RL, Diamandis EP (August 2007). "B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression". Gynecologic Oncology. 106 (2): 334–41. doi:10.1016/j.ygyno.2007.03.035. PMID 17498784.
• Miyatake T, Tringler B, Liu W, Liu SH, Papkoff J, Enomoto T, Torkko KC, Dehn DL, Swisher A, Shroyer KR (July 2007). "B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration". Gynecologic Oncology. 106 (1): 119–27. doi:10.1016/j.ygyno.2007.03.039. PMID 17509674.