Bromodomain and WD repeat-containing protein 1

Bromodomain and WD repeat-containing protein 1 (BRWD1) also known as WD repeat-containing protein 9 (WDR9) is a protein that in humans is encoded by the BRWD1 gene.

BRWD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q2E
Identifiers
Aliases	BRWD1, C21orf107, N143, WDR9, DCAF19, bromodomain and WD repeat domain containing 1, WRD9
External IDs	OMIM: 617824; MGI: 1890651; HomoloGene: 23130; GeneCards: BRWD1; OMA:BRWD1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) Band 21q22.2 Start 39,184,176 bp End 39,321,559 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C4 Start 95,793,292 bp End 95,883,726 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon middle temporal gyrus Brodmann area 23 secondary oocyte nucleus accumbens testicle epithelium of colon prefrontal cortex ganglionic eminence Top expressed in zygote ascending aorta aortic valve medial ganglionic eminence spermatid neural layer of retina ventricular zone spermatocyte secondary oocyte tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component nucleolus nucleus nucleoplasm cytoplasm cytosol Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated cytoskeleton organization transcription, DNA-templated regulation of cell shape chromatin organization interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54014 93871 Ensembl ENSG00000185658 ENSMUSG00000022914 UniProt Q9NSI6 Q921C3 RefSeq (mRNA) NM_001007246 NM_018963 NM_033656 NM_001103179 NM_145125 NM_176928 RefSeq (protein) NP_001007247 NP_061836 NP_387505 NP_001096649 NP_660107 NP_795902 Location (UCSC) Chr 21: 39.18 – 39.32 Mb Chr 16: 95.79 – 95.88 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and 8 WD repeats, and the function of this protein is not known. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates 3 transcript variants diverging at the 3' ends.

See also

• BRWD3
• WDR11, also known as BRWD2

External links

• Human BRWD1 genome location and BRWD1 gene details page in the UCSC Genome Browser.

Further reading

• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Huang H, Rambaldi I, Daniels E, Featherstone M (2004). "Expression of the Wdr9 gene and protein products during mouse development". Dev. Dyn. 227 (4): 608–14. doi:10.1002/dvdy.10344. PMID 12889071. S2CID 2056808.
• Ramos VC, Vidal-Taboada J, Bergoñon S, et al. (2002). "Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21". Biochim. Biophys. Acta. 1577 (3): 377–83. doi:10.1016/s0167-4781(02)00421-9. PMID 12359327.
• Vidal-Taboada JM, Bergoñón S, Sánchez M, et al. (1998). "High resolution physical mapping and identification of transcribed sequences in the Down syndrome region-2". Biochem. Biophys. Res. Commun. 243 (2): 572–8. doi:10.1006/bbrc.1998.8141. PMID 9480850.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.