BTS 74,398

BTS 74,398
Identifiers
	IUPAC name 1-([1-(3,4-dichlorophenyl)cyclobutyl]-2-(3-diaminethylaminopropylthio)ethanone;
CAS Number	548491-50-5;
PubChem CID	24838024;
ChemSpider	26325181 ;
UNII	I3W0WCC63A;
CompTox Dashboard (EPA)	DTXSID801027130 ;
Chemical and physical data
Formula	C19H29Cl2N3OS
Molar mass	418.42 g·mol−1
3D model (JSmol)	Interactive image; Interactive image;
	SMILES NCCN(CCN)CCCSCC(=O)C2(CCC2)c(cc1Cl)ccc1Cl; ; c1cc(c(cc1C2(CCC2)C(=O)CSCCCN(CCN)CCN)Cl)Cl;
	InChI InChI=1S/C19H29Cl2N3OS/c20-16-4-3-15(13-17(16)21)19(5-1-6-19)18(25)14-26-12-2-9-24(10-7-22)11-8-23/h3-4,13H,1-2,5-12,14,22-23H2 ; Key:OLQJWCYRPYGTJI-UHFFFAOYSA-N ;
	(verify)

BTS 74,398 is a centrally acting stimulant drug which was developed for the treatment of Parkinson's disease. It inhibits the synaptic reuptake of dopamine, serotonin and noradrenaline, making it a triple reuptake inhibitor.^[1] It was effective in animal models of Parkinson's disease,^[2]^[3] but was unsuccessful in human trials.^[4]

References

^ Lane EL, Cheetham S, Jenner P (March 2005). "Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors". The Journal of Pharmacology and Experimental Therapeutics. 312 (3): 1124–31. doi:10.1124/jpet.104.076554. PMID 15542624. S2CID 8208352.
^ Hansard MJ, Smith LA, Jackson MJ, Cheetham SC, Jenner P (January 2004). "The monoamine reuptake inhibitor BTS 74 398 fails to evoke established dyskinesia but does not synergise with levodopa in MPTP-treated primates". Movement Disorders. 19 (1): 15–21. doi:10.1002/mds.10596. PMID 14743355. S2CID 26120965.
^ Lane EL, Cheetham SC, Jenner P (January 2005). "Repeated administration of the monoamine reuptake inhibitor BTS 74 398 induces ipsilateral circling in the 6-hydroxydopamine lesioned rat without sensitizing motor behaviours". The European Journal of Neuroscience. 21 (1): 179–86. doi:10.1111/j.1460-9568.2004.03834.x. PMID 15654855. S2CID 22417785.
^ Lane EL, Cheetham S, Jenner P (2008). "Striatal output markers do not alter in response to circling behaviour in 6-OHDA lesioned rats produced by acute or chronic administration of the monoamine uptake inhibitor BTS 74 398". Journal of Neural Transmission. 115 (3): 423–9. doi:10.1007/s00702-007-0854-x. PMID 18250952. S2CID 195993.

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

This article about an amine is a stub. You can help Wikipedia by expanding it.

Identifiers

IUPAC name 1-([1-(3,4-dichlorophenyl)cyclobutyl]-2-(3-diaminethylaminopropylthio)ethanone
CAS Number	548491-50-5
PubChem CID	24838024
ChemSpider	26325181^Y
UNII	I3W0WCC63A
CompTox Dashboard (EPA)	DTXSID801027130
Chemical and physical data
Formula	C₁₉H₂₉Cl₂N₃OS
Molar mass	418.42 g·mol⁻¹
3D model (JSmol)	Interactive image Interactive image
SMILES NCCN(CCN)CCCSCC(=O)C2(CCC2)c(cc1Cl)ccc1Cl c1cc(c(cc1C2(CCC2)C(=O)CSCCCN(CCN)CCN)Cl)Cl
InChI InChI=1S/C19H29Cl2N3OS/c20-16-4-3-15(13-17(16)21)19(5-1-6-19)18(25)14-26-12-2-9-24(10-7-22)11-8-23/h3-4,13H,1-2,5-12,14,22-23H2^Y Key:OLQJWCYRPYGTJI-UHFFFAOYSA-N^Y
(verify)