Monobenzone, also called 4-(Benzyloxy)phenol and monobenzyl ether of hydroquinone (MBEH) is an organic chemical in the phenol family with chemical formula C6H5CH2OC6H4OH.[1][2] It is used as a topical drug for medical depigmentation.[3] It is a colourless solid that is classified as the monobenzyl ether of hydroquinone. Monobenzone is soluble in alcohol, benzene, and diethyl ether, and practically insoluble in water.
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| Other names | Hydroquinone benzyl ether, Hydroquinone monobenzyl ether, Benzyl p-hydroxyphenyl ether, Benzyl hydroquinone, Benzoquin, 4-(phenylmethoxy)phenol |
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| Routes of administration | Topical |
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| ECHA InfoCard | 100.002.804 |
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| Formula | C13H12O2 |
| Molar mass | 200.237 g·mol−1 |
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Pharmacology
editThe topical application of monobenzone in animals increases the excretion of melanin from melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation. [citation needed]
The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo; the epidermis is normal except for the absence of identifiable melanocytes. Therefore, monobenzone is used as a topical medicine to permanently depigment normal skin surrounding vitiliginous lesions only in patients with disseminated (greater than 50 percent of body surface area) idiopathic vitiligo. Monobenzone is also being considered for the treatment of melanoma.[4]
References
edit- ^ "4-(Benzyloxy)phenol - Substance Summary". PubChem. U.S. National Library of Medicine. Retrieved 9 September 2013.
- ^ "4-(Benzyloxy)phenol, 98%". ChemExper. Retrieved 9 September 2013.
- ^ "Monobenzone topical". eMedicineHealth. WebMD, Inc. Archived from the original on 22 March 2017.
- ^ "Monobenzone as Immunotherapy for Melanoma". jwatch. Archived from the original on 2013-01-01. Retrieved 2012-06-26.
Further reading
edit- Bolognia JL, Lapia K, Somma S (January 2001). "Depigmentation therapy. Dermatologic Therapy". 14 (1): 29–34. doi:10.1046/j.1529-8019.2001.014001029.x. S2CID 221649640.
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External links
edit- "Monobenzone". Drug Information Portal. U.S. National Library of Medicine.