Benzoate—CoA ligase

(Redirected from Benzoate-CoA ligase)

In enzymology, a benzoate—CoA ligase (EC 6.2.1.25) is an enzyme that catalyzes the chemical reaction

Benzoate—CoA ligase
Identifiers
EC no.6.2.1.25
CAS no.95329-17-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
ATP + benzoate + CoA AMP + diphosphate + benzoyl-CoA

The 3 substrates of this enzyme are ATP, benzoate, and CoA, whereas its 3 products are AMP, diphosphate, and benzoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is benzoate:CoA ligase (AMP-forming). Other names in common use include benzoate-coenzyme A ligase, benzoyl-coenzyme A synthetase, and benzoyl CoA synthetase (AMP forming). This enzyme participates in benzoate degradation via coa ligation.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2V7B.

References

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  • Hutber GN; Ribbons DW (1983). "Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris". J. Gen. Microbiol. 129 (8): 2413–2420. doi:10.1099/00221287-129-8-2413.
  • Schennen U, Braun K, Knackmuss HJ (1985). "Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria". J. Bacteriol. 161 (1): 321–5. doi:10.1128/JB.161.1.321-325.1985. PMC 214874. PMID 2857161.