BCL2L11

Bcl-2-like protein 11, commonly called BIM (Bcl-2 Interacting Mediator of cell death), is a protein that in humans is encoded by the BCL2L11 gene.

BCL2L11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F95, 2K7W, 2NL9, 2V6Q, 2VM6, 2WH6, 2YQ6, 2YQ7, 3D7V, 3FDL, 3IO8, 3IO9, 3KJ0, 3KJ1, 3KJ2, 4A1U, 4A1W, 4B4S, 4D2M, 4QVF, 4UF3, 4YJ4, 4ZIF, 4ZIH, 5AGW, 5AGX, 5C3G
Identifiers
Aliases	BCL2L11, BAM, BIM, BOD, BCL2 like 11
External IDs	OMIM: 603827; MGI: 1197519; HomoloGene: 7643; GeneCards: BCL2L11; OMA:BCL2L11 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q13 Start 111,119,378 bp End 111,168,445 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 F1 Start 127,967,958 bp End 128,004,467 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm palpebral conjunctiva epithelium of nasopharynx mucosa of paranasal sinus superficial temporal artery gingival epithelium monocyte mucosa of colon mucosa of sigmoid colon jejunal mucosa Top expressed in transitional epithelium of urinary bladder vestibular membrane of cochlear duct ciliary body internal carotid artery retinal pigment epithelium utricle Rostral migratory stream external carotid artery blood endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding microtubule binding dynein complex binding protein heterodimerization activity protein kinase binding Cellular component cytoplasm cytosol membrane intracellular membrane-bounded organelle BIM-BCL-2 complex mitochondrial outer membrane BIM-BCL-xl complex cytoplasmic dynein complex mitochondrion microtubule endomembrane system extrinsic component of membrane Bcl-2 family protein complex Biological process leukocyte homeostasis regulation of apoptotic process positive regulation of protein homooligomerization male gonad development positive regulation of cell death positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway B cell apoptotic process kidney development thymus development lymphocyte homeostasis positive regulation of apoptotic process by virus myeloid cell homeostasis post-embryonic animal organ morphogenesis ear development in utero embryonic development B cell homeostasis spleen development thymocyte apoptotic process post-embryonic development response to endoplasmic reticulum stress mammary gland development T cell homeostasis odontogenesis of dentin-containing tooth positive regulation of IRE1-mediated unfolded protein response positive regulation of cysteine-type endopeptidase activity involved in apoptotic process tube formation brain development positive regulation of neuron apoptotic process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway positive regulation of cell cycle positive regulation of mitochondrial membrane permeability involved in apoptotic process meiosis I spermatogenesis intrinsic apoptotic signaling pathway in response to DNA damage extrinsic apoptotic signaling pathway in absence of ligand positive regulation of apoptotic process positive regulation of fibroblast apoptotic process developmental pigmentation positive regulation of release of cytochrome c from mitochondria regulation of developmental pigmentation cell-matrix adhesion regulation of organ growth activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of intrinsic apoptotic signaling pathway apoptotic process involved in embryonic digit morphogenesis apoptotic process protein insertion into mitochondrial membrane involved in apoptotic signaling pathway positive regulation of autophagy in response to ER overload cellular response to glucocorticoid stimulus cellular response to estradiol stimulus cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10018 12125 Ensembl ENSG00000153094 ENSMUSG00000027381 UniProt O43521 O54918 RefSeq (mRNA) NM_001204106 NM_001204107 NM_001204108 NM_001204109 NM_001204110 NM_001204111 NM_001204112 NM_001204113 NM_006538 NM_138621 NM_138622 NM_138623 NM_138624 NM_138625 NM_138626 NM_138627 NM_207002 NM_207003 NM_001284410 NM_001291016 NM_009754 NM_207680 NM_207681 RefSeq (protein) NP_001191035 NP_001191036 NP_001191037 NP_001191038 NP_001191039 NP_001191040 NP_001191041 NP_001191042 NP_006529 NP_619527 NP_619528 NP_619529 NP_619530 NP_619531 NP_619532 NP_619533 NP_996885 NP_996886 NP_001271339 NP_001277945 NP_033884 NP_997563 NP_997564 NP_001392986 NP_001392987 NP_001392988 NP_001392989 NP_001392990 Location (UCSC) Chr 2: 111.12 – 111.17 Mb Chr 2: 127.97 – 128 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1 (FoxO3a), which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Regulation of Bim

Bim expression and activity are regulated at the transcriptional, translational and post-translational levels; coordinated expression and activity of Bim shape immune responses, and ensure tissue integrity. Cancer cells develop mechanisms that suppress Bim expression, which allows for tumor progression and metastasis.

Interactions

BCL2L11 has been shown to interact with:

• BCL2-like 1,
• BCL2L2,
• Bcl-2,
• DYNLL1, and
• MCL1.

See also

• Bcl-2

Further reading

• Wang K, Yin XM, Chao DT, et al. (1996). "BID: a novel BH3 domain-only death agonist". Genes Dev. 10 (22): 2859–69. doi:10.1101/gad.10.22.2859. PMID 8918887.
• Zha J, Harada H, Yang E, et al. (1997). "Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)". Cell. 87 (4): 619–28. doi:10.1016/S0092-8674(00)81382-3. PMID 8929531. S2CID 860908.
• Huang DC, Adams JM, Cory S (1998). "The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4". EMBO J. 17 (4): 1029–39. doi:10.1093/emboj/17.4.1029. PMC 1170452. PMID 9463381.
• Puthalakath H, Huang DC, O'Reilly LA, et al. (1999). "The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex". Mol. Cell. 3 (3): 287–96. doi:10.1016/S1097-2765(00)80456-6. PMID 10198631.
• Ohi N, Tokunaga A, Tsunoda H, et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region". Cell Death Differ. 6 (4): 314–25. doi:10.1038/sj.cdd.4400493. PMID 10381623.
• Bouillet P, Metcalf D, Huang DC, et al. (1999). "Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity". Science. 286 (5445): 1735–8. doi:10.1126/science.286.5445.1735. PMID 10576740.
• Dijkers PF, Medema RH, Lammers JW, et al. (2000). "Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1". Curr. Biol. 10 (19): 1201–4. Bibcode:2000CBio...10.1201D. doi:10.1016/S0960-9822(00)00728-4. PMID 11050388. S2CID 17945478.
• Bouillet P, Zhang LC, Huang DC, et al. (2001). "Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim". Mamm. Genome. 12 (2): 163–8. doi:10.1007/s003350010242. PMID 11210187. S2CID 7225766.
• Putcha GV, Moulder KL, Golden JP, et al. (2001). "Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis". Neuron. 29 (3): 615–28. doi:10.1016/S0896-6273(01)00238-0. PMID 11301022. S2CID 16223140.
• Murray S, Halford S, Ebenezer ND, et al. (2001). "Assignment of BCL2L11 to human chromosome band 2p13 with somatic cell and radiation hybrids". Cytogenet. Cell Genet. 92 (3–4): 353. doi:10.1159/000056930. PMID 11435715. S2CID 32790948.
• Cheng EH, Wei MC, Weiler S, et al. (2001). "BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis". Mol. Cell. 8 (3): 705–11. doi:10.1016/S1097-2765(01)00320-3. PMID 11583631.
• Mami U, Miyashita T, Shikama Y, et al. (2002). "Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family". FEBS Lett. 509 (1): 135–41. doi:10.1016/S0014-5793(01)03145-3. PMID 11734221. S2CID 82875886.
• Bouillet P, Purton JF, Godfrey DI, et al. (2002). "BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes". Nature. 415 (6874): 922–6. doi:10.1038/415922a. PMID 11859372. S2CID 1404636.
• Marani M, Tenev T, Hancock D, et al. (2002). "Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis". Mol. Cell. Biol. 22 (11): 3577–89. doi:10.1128/MCB.22.11.3577-3589.2002. PMC 133811. PMID 11997495.
• Liu JW, Chandra D, Tang SH, et al. (2002). "Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim". Cancer Res. 62 (10): 2976–81. PMID 12019181.
• Terradillos O, Montessuit S, Huang DC, Martinou JC (2002). "Direct addition of BimL to mitochondria does not lead to cytochrome c release". FEBS Lett. 522 (1–3): 29–34. doi:10.1016/S0014-5793(02)02871-5. PMID 12095614. S2CID 20419085.
• Sugiyama T, Shimizu S, Matsuoka Y, et al. (2002). "Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim". Oncogene. 21 (32): 4944–56. doi:10.1038/sj.onc.1205621. PMID 12118373.

External links

• BCL2L11 human gene location in the UCSC Genome Browser.
• BCL2L11 human gene details in the UCSC Genome Browser.