Brandejs is a Czech-language surname, a variant of Brandeis.
The surname may refer to:
- Adam Brandejs, Canadian artist, and author of Genpets
- Václav Brandejs and Ivan Brandejs, founders of ProFe, a Czech aircraft manufacturer
- Petr Brandejs, past banjo of the Czech bluegrass band Poutníci
- Milan Brandejs, mayor of Teplice nad Metují (as of 2013)