Bromodifluoroacetyl chloride is a chemical compound with the formula BrCF2COCl. It has been used as a starting material for the synthesis of (biologically active) α,α-difluoro-γ-lactams[1] and has been used in the synthesis of trifluoromethylated C-nucleosides.[2]
| |
| |
| Names | |
|---|---|
| Preferred IUPAC name
Bromodi(fluoro)acetyl chloride | |
| Other names
2-Bromo-2,2-difluoroacetyl chloride
2-Bromo-2,2-difluoro-ethanoyl chloride | |
| Identifiers | |
3D model (JSmol)
|
|
| ChemSpider | |
| ECHA InfoCard | 100.197.413 |
| EC Number |
|
PubChem CID
|
|
CompTox Dashboard (EPA)
|
|
| |
| |
| Properties | |
| C2BrClF2O | |
| Molar mass | 193.37 g·mol−1 |
| Appearance | liquid |
| Boiling point | 50 °C (122 °F; 323 K) |
| Hazards | |
| GHS labelling: | |
 
| |
| Danger | |
| H226, H314 | |
| P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P370+P378, P403+P235, P405, P501 | |
| Safety data sheet (SDS) | [1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
See also
editReferences
edit- ^ Nagashima, H.; Isono, Y.; Iwamatsu, S. (2001). "Copper-Catalyzed Cyclization of N-Allylhalodifluoroacetamides: An Efficient Synthesis of α,α-difluoro-γ-lactams". Journal of Organic Chemistry. 66 (1): 315–319. doi:10.1021/jo001187f. PMID 11429918.
- ^ Mamata, C.; Heina, M.; Miethchen, R. (2006). "Fluorinated acyclo-C-nucleoside analogues from glycals in two steps". Carbohydrate Research. 341 (10): 1758–1763. doi:10.1016/j.carres.2006.01.011. PMID 16442508.
 | This article about an organic halide is a stub. You can help Wikipedia by expanding it. |