Calcyphosin

Calcyphosin is a protein that in humans is encoded by the CAPS gene.

CAPS
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3E3R
Identifiers
Aliases	CAPS, CAPS1, calcyphosine
External IDs	OMIM: 114212; HomoloGene: 37871; GeneCards: CAPS; OMA:CAPS - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 5,912,339 bp End 5,916,211 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell right uterine tube olfactory zone of nasal mucosa nasal epithelium mucosa of paranasal sinus trachea pancreatic ductal cell superior vestibular nucleus tibial nerve epithelium of nasopharynx n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding calcium ion binding Cellular component vesicle extracellular exosome cytoplasm nucleus plasma membrane Biological process intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 828 n/a Ensembl ENSG00000105519 n/a UniProt Q13938 n/a RefSeq (mRNA) NM_004058 NM_080590 n/a RefSeq (protein) NP_004049 NP_542157 n/a Location (UCSC) Chr 19: 5.91 – 5.92 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Function

This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants.

Further reading

• Lefort A, Lecocq R, Libert F, et al. (1989). "Cloning and sequencing of a calcium-binding protein regulated by cyclic AMP in the thyroid". EMBO J. 8 (1): 111–6. doi:10.1002/j.1460-2075.1989.tb03354.x. PMC 400778. PMID 2540953.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Clément S, Dumont JE, Schurmans S (1997). "Loss of calcyphosine gene expression in mouse and other rodents". Biochem. Biophys. Res. Commun. 232 (2): 407–13. doi:10.1006/bbrc.1997.6297. PMID 9125191.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.