CDC2L1

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDK11B gene.

CDK11B
Identifiers
Aliases	CDK11B, CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PITSLREA, PK58, p58, p58CDC2L1, p58CLK-1, cyclin-dependent kinase 11B, cyclin dependent kinase 11B
External IDs	OMIM: 176873; MGI: 88353; HomoloGene: 137644; GeneCards: CDK11B; OMA:CDK11B - orthologs
EC number	2.7.11.22
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.33 Start 1,635,225 bp End 1,659,012 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 E2|4 86.73 cM Start 155,624,854 bp End 155,649,938 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastrocnemius muscle gastric mucosa left testis muscle layer of sigmoid colon right testis granulocyte mucosa of transverse colon muscle of thigh right lung Top expressed in granulocyte tail of embryo neural layer of retina saccule genital tubercle otic placode ventricular zone otic vesicle epiblast body of femur More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding kinase activity nucleotide binding transferase activity protein serine/threonine kinase activity ATP binding protein kinase activity cyclin-dependent protein serine/threonine kinase activity RNA binding Cellular component nucleus cytoplasm Biological process regulation of transcription, DNA-templated phosphorylation cell cycle regulation of cell growth cell population proliferation regulation of mRNA processing apoptotic process protein phosphorylation regulation of mitotic cell cycle mitotic cell cycle regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 984 12537 Ensembl ENSG00000248333 ENSMUSG00000029062 UniProt P21127 P24788 RefSeq (mRNA) NM_001291345 NM_001787 NM_033486 NM_033487 NM_033488 NM_033489 NM_033490 NM_033492 NM_033493 NM_007661 NM_001347308 NM_001355567 NM_001355568 NM_001355569 RefSeq (protein) NP_001278274 NP_001778 NP_277021 NP_277022 NP_277024 NP_277025 NP_001334237 NP_031687 NP_001342496 NP_001342497 NP_001342498 Location (UCSC) Chr 1: 1.64 – 1.66 Mb Chr 4: 155.62 – 155.65 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.

Interactions

CDC2L1 has been shown to interact with Cyclin D3.

Further reading

• Eipers PG, Lahti JM, Kidd VJ (1992). "Structure and expression of the human p58clk-1 protein kinase chromosomal gene". Genomics. 13 (3): 613–21. doi:10.1016/0888-7543(92)90132-C. PMID 1639388.
• Bunnell BA, Heath LS, Adams DE, et al. (1990). "Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7467–71. Bibcode:1990PNAS...87.7467B. doi:10.1073/pnas.87.19.7467. PMC 54768. PMID 2217177.
• White PS, Maris JM, Beltinger C, et al. (1995). "A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5520–4. Bibcode:1995PNAS...92.5520W. doi:10.1073/pnas.92.12.5520. PMC 41727. PMID 7777541.
• Lahti JM, Valentine M, Xiang J, et al. (1994). "Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma". Nat. Genet. 7 (3): 370–5. doi:10.1038/ng0794-370. PMID 7920654. S2CID 2065302.
• Xiang J, Lahti JM, Grenet J, et al. (1994). "Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms". J. Biol. Chem. 269 (22): 15786–94. doi:10.1016/S0021-9258(17)40749-6. PMID 8195233.
• Beyaert R, Kidd VJ, Cornelis S, et al. (1997). "Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor". J. Biol. Chem. 272 (18): 11694–7. doi:10.1074/jbc.272.18.11694. PMID 9115219.
• Loyer P, Trembley JH, Lahti JM, Kidd VJ (1998). "The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo". J. Cell Sci. 111 (11): 1495–506. doi:10.1242/jcs.111.11.1495. PMID 9580558.
• Tang D, Gururajan R, Kidd VJ (1998). "Phosphorylation of PITSLRE p110 isoforms accompanies their processing by caspases during Fas-mediated cell death". J. Biol. Chem. 273 (26): 16601–7. doi:10.1074/jbc.273.26.16601. PMID 9632733.
• Gururajan R, Lahti JM, Grenet J, et al. (1998). "Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2". Genome Res. 8 (9): 929–39. doi:10.1101/gr.8.9.929. PMC 310781. PMID 9750192.
• Cornelis S, Bruynooghe Y, Denecker G, et al. (2000). "Identification and characterization of a novel cell cycle-regulated internal ribosome entry site". Mol. Cell. 5 (4): 597–605. doi:10.1016/S1097-2765(00)80239-7. PMID 10882096.
• Trembley JH, Hu D, Hsu LC, et al. (2002). "PITSLRE p110 protein kinases associate with transcription complexes and affect their activity". J. Biol. Chem. 277 (4): 2589–96. doi:10.1074/jbc.M109755200. PMID 11709559.
• Zhang S, Cai M, Zhang S, et al. (2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3". J. Biol. Chem. 277 (38): 35314–22. doi:10.1074/jbc.M202179200. PMID 12082095.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hu D, Mayeda A, Trembley JH, et al. (2003). "CDK11 complexes promote pre-mRNA splicing". J. Biol. Chem. 278 (10): 8623–9. doi:10.1074/jbc.M210057200. PMID 12501247.
• Chen S, Yin X, Zhu X, et al. (2003). "The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis". J. Biol. Chem. 278 (22): 20029–36. doi:10.1074/jbc.M300818200. PMID 12624090.
• de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
• Sachs NA, Vaillancourt RR (2004). "Cyclin-dependent kinase 11p110 and casein kinase 2 (CK2) inhibit the interaction between tyrosine hydroxylase and 14-3-3". J. Neurochem. 88 (1): 51–62. doi:10.1046/j.1471-4159.2003.02119.x. PMID 14675149.

External links

• Human CDK11B genome location and CDK11B gene details page in the UCSC Genome Browser.