CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene. [5]
CDC42EP5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CDC42EP5, Borg3, CEP5, CDC42 effector protein 5 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 609171; MGI: 1929745; HomoloGene: 10984; GeneCards: CDC42EP5; OMA:CDC42EP5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
editCell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013].
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000167617 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063838 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: CDC42 effector protein 5". Retrieved 2018-04-25.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.