Cyclin-dependent kinase 10

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.

CDK10
Identifiers
Aliases	CDK10, PISSLRE, cyclin-dependent kinase 10, cyclin dependent kinase 10, ALSAS
External IDs	OMIM: 603464; MGI: 2448549; HomoloGene: 55769; GeneCards: CDK10; OMA:CDK10 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q24.3 Start 89,680,737 bp End 89,696,354 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 E1 Start 123,951,581 bp End 123,958,989 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lobe of thyroid gland left lobe of thyroid gland anterior pituitary body of pancreas right lobe of liver granulocyte mucosa of transverse colon apex of heart right hemisphere of cerebellum Top expressed in otic vesicle superior frontal gyrus neural layer of retina primary visual cortex dentate gyrus of hippocampal formation granule cell spermatocyte otolith organ utricle hand lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity cyclin-dependent protein kinase activity protein binding ATP binding kinase activity cyclin-dependent protein serine/threonine kinase activity protein serine/threonine kinase activity Cellular component mediator complex ciliary basal body cytoplasm cytoskeleton cell projection nucleus Biological process traversing start control point of mitotic cell cycle phosphorylation positive regulation of MAPK cascade negative regulation of cell population proliferation protein phosphorylation peptidyl-threonine phosphorylation regulation of actin cytoskeleton organization negative regulation of cilium assembly cell projection organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8558 234854 Ensembl ENSG00000185324 ENSMUSG00000033862 UniProt Q15131 Q3UMM4 RefSeq (mRNA) NM_001098533 NM_001160367 NM_003674 NM_052987 NM_052988 NM_194444 NM_194446 RefSeq (protein) NP_001092003 NP_001153839 NP_443713 NP_443714 NP_919426 NP_919428 Location (UCSC) Chr 16: 89.68 – 89.7 Mb Chr 8: 123.95 – 123.96 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.

Interactions

Cyclin-dependent kinase 10 has been shown to interact with ETS2.

Further reading

• Li S, MacLachlan TK, De Luca A, Claudio PP, Condorelli G, Giordano A (1995). "The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle". Cancer Res. 55 (18): 3992–5. PMID 7664269.
• Bullrich F, MacLachlan TK, Sang N, Druck T, Veronese ML, Allen SL, Chiorazzi N, Koff A, Heubner K, Croce CM (1995). "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res. 55 (6): 1199–205. PMID 7882308.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Crawford J, Ianzano L, Savino M, Whitmore S, Cleton-Jansen AM, Settasatian C, d'apolito M, Seshadri R, Pronk JC, Auerbach AD, Verlander PC, Mathew CG, Tipping AJ, Doggett NA, Zelante L, Callen DF, Savoia A (1999). "The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer". Genomics. 56 (1): 90–7. doi:10.1006/geno.1998.5676. PMID 10036189.
• Sergère JC, Thuret JY, Le Roux G, Carosella ED, Leteurtre F (2000). "Human CDK10 gene isoforms". Biochem. Biophys. Res. Commun. 276 (1): 271–7. doi:10.1006/bbrc.2000.3395. PMID 11006117.
• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Kasten M, Giordano A (2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID 11313931. S2CID 22792083.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. hdl:10033/19756. PMID 17192257.

External links

• CDK10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)